1. PETASIS BORONIC ACID-MANNICH REACTION
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2. PETASIS BORONIC ACID-MANNICH REACTION
The Petasis reaction (alternatively called the Petasis borono–Mannich (PBM) reaction) is the chemical reaction of an amine, aldehyde, and vinyl- or aryl-boronic acid to form substituted amines.
Mannich reaction ：
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3. PETASIS BORONIC ACID-MANNICH REACTION
Mechanism
The reaction does not go through intermediate A. Both intermediate B and C can promote the formation of the product. Most likely, the reaction proceeds through intermediate C, where the hydroxyl group attacks the electrophilic boron leading to an “ate”-complex. Subsequent vinyl transfer provides the allylic amine along with the boronic acid sideproduct.
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4. PETASIS BORONIC ACID-MANNICH REACTION
Mechanism
 Petasis, N.A. (2005). Zhu, J.; Bienayme, H., eds. Multicomponent Reactions. Wiley-VCH. pp. 199–223. doi: / ch7
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5. PETASIS BORONIC ACID-MANNICH REACTION
Synthetic Applications:
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6. PETASIS BORONIC ACID-MANNICH REACTION
Synthetic Applications:
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7. PETASIS BORONIC ACID-MANNICH REACTION
Synthetic Applications:
Lou, S.; Schaus, S.E. (2008). "Asymmetric petasis reactions catalyzed by chiral biphenols". 
J. Am. Chem. Soc. 130 (22): 6922–6923. doi: /ja  
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8. PETASIS BORONIC ACID-MANNICH REACTION
Synthetic Applications:
 Han, W.-Y.; Wu, Z.-J.; Zhang, X.-M.; Yuan, W.-C. (2012), "Enantioselective Organocatalytic Three-Component Petasis Reaction among Salicylaldehydes, Amines, and Organoboronic Acids", Org. Lett., ASAP (4): 976–979, doi: /ol203109a
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