1. Glucose degradation via the Entner-Doudoroff (ED) pathways known for Bacteria (classical) and the modified branched versions reported for Archaea.
Glucose degradation via the Entner-Doudoroff (ED) pathways known for Bacteria (classical) and the modified branched versions reported for Archaea. The nonphosphorylative ED (npED) and the semiphosphorylative ED (spED) branches in Archaea, with phosphorylation at the level of glycerate and 2-keto-3-deoxygluconate (KDG), respectively, are shown. Abbreviations: 6PGD (EDD), gluconate-6-phosphate dehydratase; ENO, enolase; G6PDH (Zwf), glucose-6-phosphate dehydrogenase; GAD, gluconate dehydratase; GADH, glyceraldehyde dehydrogenase; GAOR, glyceraldehyde:ferredoxin oxidoreductase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GAPN, nonphosphorylating GAPDH; GAPOR, GAP:Fd oxidoreductase; GDH, glucose dehydrogenase; GK, glycerate kinase; GLac, gluconolactonase; GLK, glucokinase; HK, hexokinase; KDGK, 2-keto-3-deoxygluconate kinase; KDPGA (EDA), 2-keto-3-deoxy-6-phosphogluconate aldolase; KD(P)GA, 2-keto-3-deoxy-(6-phospho)gluconate aldolase; PGK, phosphoglycerate kinase; PGL, 6-phosphoglucono-1,4-lactonase; PGAM, phosphoglycerate mutase (dPGAM, 2,3BPG cofactor dependent; iPGAM, 2,3BPG cofactor independent); PK, pyruvate kinase; PEPS, PEP synthetase; PPDK, pyruvate:phosphate dikinase; PTS, PEP-dependent phosphotransferase system; G6P, glucose 6-phosphate; GAP, glyceraldehyde 3-phosphate; 1,3BPG, 1,3-bisphosphoglycerate; 3PG, 3-phosphoglycerate; 2PG, 2-phosphoglycerate; PEP, phosphoenolpyruvate; KDG, 2-keto-3-deoxygluconate; KDPG, 2-keto-3-deoxy-6-phosphogluconate; GA, glyceraldehyde.
Christopher Bräsen et al. Microbiol. Mol. Biol. Rev. 2014; doi: /MMBR