1. CD9 Is a Novel Target in Glomerular Diseases Typified by Parietal Epithelial Cell Activation 
Bart Smeets, Laura Miesen, Stuart J. Shankland 
American Journal of Kidney Diseases 
DOI: /j.ajkd
Copyright © 2019 National Kidney Foundation, Inc. Terms and Conditions

2. Figure 1
Schematic representation of the key findings of the study by Lazareth et al.7 (A) Normal glomerulus. In health, CD9 is not expressed within the glomerulus. (B) Disease. In focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (GN), CD9 is expressed de novo by parietal epithelial cells (PECs), which mediates PEC activation. Activated PECs (red) undergo increased proliferation and migration and form extracapillary lesions, including crescents. (C) Proposed mechanisms of CD9-induced PEC activation. Tetraspanin CD9 distributes adhesion and signaling proteins (PDGF, CD44, ITGB1, and EGFR) into highly organized signaling microdomains that regulate the switch from a quiescent to an active PEC. Figure created with biorender.com.
American Journal of Kidney Diseases DOI: ( /j.ajkd )
Copyright © 2019 National Kidney Foundation, Inc. Terms and Conditions