1. Insights into obesity and diabetes at the intersection of mouse and human genetics 
Melkam A. Kebede, Alan D. Attie 
Trends in Endocrinology & Metabolism 
Volume 25, Issue 10, Pages (October 2014)
DOI: /j.tem
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2. Figure 1
Linkage and association studies in mouse and human genetics. (A) Linkage studies. In human, families with affected individuals are selected. SNP genotyping is performed to identify allele sharing between affected individuals. This approach has high statistical power, but phenotypes typically map to broad chromosomal regions harboring many genes. In mouse, intercrosses between inbred mouse strains are analogous to family-based linkage studies in humans. Like human linkage studies, mouse intercrosses have high statistical power but low mapping resolution. (B) Association studies. In human, one looks for association between SNP genotypes and phenotypes across an outbred population. Because these populations segregate smaller genomic regions, the mapping resolution is much higher than is seen in linkage studies. However, the requirement to score large numbers of SNPs and ensuing multiple testing penalty results in lower statistical power. In mouse, association studies in outbred stocks are analogous to human genome-wide association studies. These studies have much higher resolution than linkage studies. They require fewer SNPs to achieve high coverage and therefore have relatively high statistical power.
Trends in Endocrinology & Metabolism  , DOI: ( /j.tem )
Copyright © 2014 Elsevier Ltd Terms and Conditions