1. WOEST
Trial design: Patients on oral anticoagulation therapy, due to atrial fibrillation or mechanical heart valve, undergoing PCI, were randomized to clopidogrel alone (n = 284) vs. aspirin 80 mg and clopidogrel (n = 289).
Results
(p < 0.001)
Total bleeding events at 1 year: 19.5% of the double therapy group vs. 44.9% of the triple therapy group (p < 0.001); primary outcome was the same among all tested subgroups
TIMI minimal bleeding: 6.5% vs. 16.7%
TIMI major bleeding: 3.3% vs. 5.8%
Death, MI, stroke, stent thrombosis, or TVR: 11.3% vs. 17.7% (p = 0.025), respectively
44.9 %
19.5
Conclusions
Among patients on oral anticoagulation therapy undergoing PCI, the use of clopidogrel alone compared with aspirin plus clopidogrel reduced the frequency of all bleeding events
This was accomplished without an increase in adverse ischemic events
Clopidogrel alone
Aspirin and clopidogrel
Presented by W. Dewilde at ESC Congress, 2012