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Photoprovocation in Cutaneous Lupus Erythematosus: A Multicenter Study Evaluating a Standardized Protocol Annegret Kuhn, Anna Wozniacka, Jacek C. Szepietowski, Regine Gläser, Percy Lehmann, Merle Haust, Anna Sysa-Jedrzejowska, Adam Reich, Vilija Oke, Rainer Hügel, Cesar Calderon, Dick E. de Vries, Filippa Nyberg Journal of Investigative Dermatology Volume 131, Issue 8, Pages (August 2011) DOI: /jid Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 1 Threshold testing values and times to onset of positive response and fully developed skin lesions. Mean±SD values from threshold testing (on day 1) for (a) immediate pigment darkening (IPD), minimal erythema dose (MED), and minimal tanning dose (MTD) in photoprovocation-positive and -negative cutaneous lupus erythematosus (CLE) subjects and for (b) MED and (c) MTD across CLE subtypes. (d) Times to the onset of positive response (black box-and-whiskers) and to fully developed skin lesion (white box-and-whiskers) after photoprovocation (on days 2–4) in photoprovocation-positive CLE subjects. Box-and-whisker plots present the median, interquartile range, and range for each group. DLE, discoid lupus erythematosus; LET, lupus erythematosus tumidus; SCLE, subacute cutaneous lupus erythematosus. †P<0.01; *P<0.05. Journal of Investigative Dermatology , DOI: ( /jid ) Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 2 Clinical image of a typical photoprovoked lesion in a photoprovocation-positive cutaneous lupus erythematosus (CLE) subject. This photograph was taken on day 18. Bar=1mm. Journal of Investigative Dermatology , DOI: ( /jid ) Copyright © 2011 The Society for Investigative Dermatology, Inc Terms and Conditions
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