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NIH Funding for Novel Biomaterials
David Rampulla Program Director Biomaterials and Biomolecular Constructs Synthetic Biology for Technology Development Engineered Cells Technologies for Immunoengineering NIBIB/NIH
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NIH is the steward of medical and behavioral research for the Nation
NIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability. NIH is committed to Turning Discovery to Health We are the nation’s medical research agency—making important discoveries that improve health and save lives. Scope: In realizing these goals, the NIH provides leadership and direction to programs designed to improve the health of the Nation by conducting and supporting research: - in the causes, diagnosis, prevention, and cure of human diseases; - in the processes of human growth and development; - in the biological effects of environmental contaminants; - in the understanding of mental, addictive and physical disorders; and - in directing programs for the collection, dissemination, and exchange of information in medicine and health 2
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NIH FY17 Budget Total = $33.1 B About 81% distributed via Extramural grants, contracts, cooperative agreements
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NIBIB BIOENGINEERING is the BRIDGE
Other ICs study basic biology and pathology Science Applied Engineering Research Translation NIBIB BIOENGINEERING is the BRIDGE develop medical solutions Bioengineering: Transforming Science into Action Science: Gaining fundamental knowledge and understanding through open-ended study. Applied Science: Knowing the desired outcome, exploring solutions. Engineering: Harnessing what is known to build a solution to a problem. Research Engineering: Adapting technology solutions to drive science that fills the knowledge gaps. Translation: Bringing the solution to practice.
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Bioengineering at NIBIB
Biomedical Devices: - Therapeutic Medical Devices - Surgical Tools Engineered Biology: - Engineered Tissues/Tissue Chips - Engineered Cells Trans-division: - Modeling, Analysis, and Simulation - Synthetic Biology for Technology Development - Technologies for Immunoengineering enabling technologies with broad biomedical application… …explore the intersection between human biology and engineered systems Biointerfaces: - Biosensors and Physiological Detectors - Biomaterials and Biomolecular Constructss
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“Biomaterials” in the NIH Portfolio
(by percent of total investment, FY17) Total Awards = 583
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The NSF-NIH Biomaterial Hand-off
At the NSF… Greater focus on developing material properties (in general) Larger importance on ‘new’ materials and phenomena Pushing properties toward biomedical relevance Some basics… does it kill cells? At the NIH/NIBIB… Greater focus on developing the material in a biomedical context Larger importance on addressing an unmet medical need Pushing properties toward clinical relevance More in vivo (and in vitro) testing
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What Comes in the Door at NIBIB/Biomaterials?
First… contact a Program Director There are occasionally subtle differences between the missions of the institutes NIBIB is the ‘engineering’ IC Biomedical intervention Disease agnostic Biomaterials and Biomolecular Constructs Surgical sealants In vivo energy harvesters Implant coatings Tissue scaffolds Genome editors Nanoparticles for drug delivery Functional properties Biocompatibility Tends to be a ‘next step’ from NSF toward biomedical relevance Other programs at NIBIB… Imaging modalities/detectors MR, optical, ultrasound, PET/SPECT Imaging Probes Biosensors and Physiological Detectors Modeling, Analysis, and Simulation
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What’s already in the program
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Does NIH Already Support My Interest Area?
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RePORTer Delivers a Treasure Trove…
Click for Abstract
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… of Useful Information.
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R21 ($275K spread over 2 yrs, non-renewable)
Twp Two roads diverged in a wood, and I— I took the one less traveled by, And that has made all the difference. - Robert Frost R21 ($275K spread over 2 yrs, non-renewable) High(er) risk and reward Little/no supporting data R03 (2 yrs, $50K per year, non-renewal) succinct task(s) R01 (4-5 yrs, $ K+, renewable, a “real” grant) Convincing preliminary data for each aim Longer term questions Multiple complexities
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Relevant NIBIB/NIH Funding Opportunities
MOST applications come in through the Parent Mechanisms… and that’s OK! PAR : NIBIB Trailblazer Award for New and Early Stage Investigators (R21) PAR : NIBIB Exploratory/Developmental Research Grant Program (R21) PAR : NIBIB Biomedical Technology Resource Centers (P41) PAR : Bioengineering Research Partnerships (U01) Note: No specific biomaterials focused FOAs at NIBIB at this time Trans-NIH interests (Common Fund) Somatic Cell Genome Engineering: Delivery vehicles, genome editors HEAL: opioids, pain management devices, biomarkers BRAIN: mapping technologies High-risk High-reward: New Innovator, Transformative R01 Trans-NIBIB interests Synthetic Biology: using synbio approach to develop biomedical technologies Immunoengineering: developing technologies to engineer the immune system
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Study Section’s Mid-Morning Break
Conversation at the Study Section’s Mid-Morning Break PD: I think I have this figured out. You guys have pretty much decided on an impact score by the time you finish reading the Specific Aims page, right? Reviewer #1 (hesitantly): Well… yes, that’s right. PD: And the rest is filling in the details, looking for confirmation of your opinion, scanning for fatal flaws… Reviewer #2: That about sums it up, yes.
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Cover Letters Help Target Your Review
Applicants can suggest Review Group assignment Expertise necessary for a full and fair review Primary (and secondary) Institute or Center (IC) assignment Reviewers with potential conflicts Do not suggest possible reviewers, they will be disqualified. Other Important Information Reasons for a late submission Note eligibility for continuous submission Highlight this application as one of a set, if applicable Acknowledge NIH approval for acceptance of A budget >$500K/yr Conference grant Suggested format and other information at
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It’s an orderly universe. Your application is reviewed by either …
Chartered (Standing) Scientific Review Group (SRG), or “Study Section” Special Emphasis Panel (SEP) organized by the Center for Scientific Review (CSR) Conflicts on the panel (e.g. reviewer is a PI on the grant application) Special review for a unique solicitation (e.g. PAR) convened within a home IC of a highly specific initiative (e.g. RFA)
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Your application may be REVIEWED by one of:
Vascular and Hematology (VH) AICS, ELB, HM, HP, MCH, VCMB, F10B Molecular, Cellular and Developmental Neuroscience (MDCN) BPNS, CMBG, CMND, DDNS, MNPS, NCF, NDPR, NOMD, NTRC, SYN Behavior and Behavioral Processes (BBBP) APDA, BRLE, CP, CPDD, LCOM, MESH, MFSR Bioengineering Sciences and Technology (BST) BDMA, BMBI, GDD, ISD, MABS, NANO Biology of Development and Aging (BDA) International/Cooperative Projects Cell Biology (CB) BVS, NCSD, CMAD, CSRS, DEV1/2, ICI, MBPP, MIST Healthcare Delivery and Methodologies (HDM) BCHI, BMRD, CIHB, CLHP, DIRH, HDEP, HSOD, NRCS Infectious Diseases and Microbiology (IDM) BACP, CRFS, DDR, HIBP, PTHE, VB, VIRA/B, F13 AIDS and AIDS Related Research (AARR) ACE, ADDT, AIP, AMCB, AOIC, BSCH, BSPH, NAED, VACC >200 Standing Scientific Review Groups (SRGs or Study Sections) housed in 25 Integrated Review Groups at CSR Surgical Sciences and Biomedical Imaging and Bioengineering (SBIB) BMIT-A/B, BTSS, CMIP, MEDI, SAT, F15 Brain Disorders and Clinical Neuroscience (BDCN) ANIE, ASG, BINP, CDIN, CNBT, CNN, CNNT, DBD, DPVS, NPAS, PMDA Endocrinology, Metabolism, Nutrition and Reproductive Systems (EMNR) MCE, ICER, CMIR, PN, CADO, IPOD, CIDO, INMP, F06 Biological Chemistry and Molecular Biophysics (BCMB) BBM, MSFA/B/D/C/D, SBCA/B Risk Prevention and Health Behavior (RPHB) BMIO, PDRP, PRDP, RPIA, SPIP, F16 Genes, Genomes and Genetics (GGG) MGA/B, GCAT, GVE, GHD, PCMB, TAG Immunology (IMM) CMIA/B, HAI, IHD, III, IMM-M, TTT, VMD, F07 Musculoskeletal Oral and Skin Diseases (MOSS) ACTS, MRS, MTE, ODCS, SBDD, SBSR, SMEP Interdisciplinary Medical Sciences and Training (IMST) EBIT, various training Oncology 1 – Basic Translational (OBT) CAMP, CE, CG, MONC, TCB, TME, TPM Digestive, Kidney and Urological Systems (DKUS) CIMG, GMPB, HBPP, KMBD, PBKD, UGPP, XNDA Cardiovascular and Respiratory Sciences (CVRS) CCHF, CDD, CICS, ESTA, LCMI, LIRR, MIM, RIBT, F10A Oncology 2 – Translational and Clinical (OTC) BMCT, CBSS, CDP, CII, CONC, DMP, DT, RTB Emerging Technologies and Training in Neuroscience (ETTN) MNG, BNVT, NOIT, F01/2/3 Population Science and Epidemiology (PSE) BGES, CASE, EPIC, IRAP, KNOD, NAME, SSPA/B Integrative, Functional and Cognitive Neuroscience (IFCN) AUD, LAM, NAL, NMB, NNRS, SCS, SMI, SPC 18
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How to Identify the Best Study Section
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Review Group Description:
What is the science focus? Biomaterials and Biointerfaces Study Section [BMBI] Science Focus of “nearest neighbor” study sections
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SOME Biomaterials Study Sections
“Biomaterials and Biointerfaces (BMBI) - applications concerned with biologically relevant research in materials science…” “Nanotechnology (NANO) - research … relating to the unique properties of nanomaterials.” “Bioengineering, Technology, and Surgical Sciences (BTSS) - applications in the interdisciplinary fields of surgery and bioengineering…”
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David Rampulla, Ph.D. Program Director:
Biomaterials and Biomolecular Constructs Engineered Cells Synthetic Biology for Technology Development Technologies for Immunoengineering National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institutes of Health (NIH) … improving health by leading the development and accelerating the application of biomedical technologies
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