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David R. J. Glenn, M. R. C. O. G. , Carmel M. McVicar, Ph. D

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Presentation on theme: "David R. J. Glenn, M. R. C. O. G. , Carmel M. McVicar, Ph. D"— Presentation transcript:

1 Sildenafil citrate improves sperm motility but causes a premature acrosome reaction in vitro 
David R.J. Glenn, M.R.C.O.G., Carmel M. McVicar, Ph.D., Neil McClure, F.R.C.O.G., Sheena E.M. Lewis, Ph.D.  Fertility and Sterility  Volume 87, Issue 5, Pages (May 2007) DOI: /j.fertnstert Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 The effects of sildenafil on progressive motility of human sperm ▴ control sperm ° sperm incubated in the presence of 0.67 μM sildenafil citrate Values are means for 22 samples; P<.001. Glenn. Sildenafil citrate accelerates sperm function. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

3 FIGURE 2 The effect of sildenafil citrate on the velocity of human sperm ▴ control sperm ° sperm incubated in the presence of 0.67 μM sildenafil citrate Values are means for 22 samples; P<.001. Glenn. Sildenafil citrate accelerates sperm function. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

4 FIGURE 3 The effects of sildenafil citrate on sperm acrosome reactions ■ control sperm ■ sperm incubated in the presence of 0.67 μM sildenafil citrate Values are means ± SE for 33 samples.*P<.05, **P<.01, show significant differences with Student’s t-test between control samples and those exposed to 0.67 μM of sildenafil citrate. Glenn. Sildenafil citrate accelerates sperm function. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions


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