1. The Lancet Respiratory Medicine
Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial 
Richard T Davey, MD, Prof Eduardo Fernández-Cruz, MD, Prof Norman Markowitz, MD, Sarah Pett, MBBS, Prof Abdel G Babiker, PhD, Deborah Wentworth, MPh, Surender Khurana, PhD, Nicole Engen, MSc, Prof Fred Gordin, MD, Prof Mamta K Jain, MD, Prof Virginia Kan, MD, Mark N Polizzotto, MBBS, Paul Riska, MD, Prof Kiat Ruxrungtham, MD, Prof Zelalem Temesgen, MD, Prof Jens Lundgren, MD, John H Beigel, MD, H Clifford Lane, MD, Prof James D Neaton, PhD Richard T Davey, Eduardo Fernández-Cruz, Norman Markowitz, Sarah Pett, Abdel G Babiker, Deborah Wentworth, Surender Khurana, Nicole Engen, Fred Gordin, Mamta K Jain, Virginia Kan, Mark N Polizzotto, Paul Riska, Kiat Ruxrungtham, Zelalem Temesgen, Jens Lundgren, John H Beigel, H Clifford Lane, James D Neaton, Jessica Butts, Eileen Denning, Alain DuChene, Eric Krum, Merrie Harrison, Sue Meger, Ross Peterson, Kien Quan, Megan Shaughnessy, Greg Thompson, David Vock, Julia Metcalf, Robin Dewar, Tauseef Rehman, Ven Natarajan, Rose McConnell, Emily Flowers, Kenny Smith, Marie Hoover, Elizabeth M Coyle, David Munroe, Bitten Aagaard, Mary Pearson, Adam Cursley, Helen Webb, Fleur Hudson, Charlotte Russell, Aminata Sy, Cara Purvis, Brooke Jackson, Yolanda Collaco-Moraes, Dianne Carey, Rosemary Robson, Adriana Sánchez, Elizabeth Finley, Donna Conwell, Marcelo H Losso, Luciana Gambardella, Cecilia Abela, Paco Lopez, Helena Alonso, Giota Touloumi, Vicky Gioukari, Olga Anagnostou, Anchalee Avihingsanon, Kanitta Pussadee, Sasiwimol Ubolyam, Bola Omotosho, Clemencia Solórzano, Tianna Petersen, Kranthi Vysyaraju, Stacey A Rizza, Jennifer A Whitaker, Raquel Nahra, John Baxter, Patricia Coburn, Edward M Gardner, James A Scott, Leslie Faber, Erica Pastor, Linda Makohon, Rodger A MacArthur, L Monique Hillman, Marti J Farrough, Hari M Polenakovik, Linda A Clark, Roberto J Colon, Ken M Kunisaki, Miranda DeConcini, Susan A Johnson, Cameron R Wolfe, Laura Mkumba, June Y Carbonneau, Alison Morris, Meghan E Fitzpatrick, Cathy J Kessinger, Robert A Salata, Karen A Arters, Catherine M Tasi, Ralph J Panos, Laura A Lach, Marshall J Glesby, Kirsis A Ham, Valery G Hughes, Robert T Schooley, Daniel Crouch, Leticia Muttera, Richard M Novak, Susan C Bleasdale, Ariel E Zuckerman, Weerawat Manosuthi, Supeda Thaonyen, Thaniya Chiewcharn, Gompol Suwanpimolkul, Sivaporn Gatechumpol, Sirikunya Bunpasang, Brian J Angus, Monique Anderson, Marcus Morgan, Jane Minton, Maria N Gkamaletsou, Joe Hambleton, David A Price, Martin J Llewelyn, Jonathan Sweetman, Javier Carbone, Jose R Arribas, Rocio Montejano, Jose L Lobo Beristain, Iñaki Z Martinez, Jose Barberan, Paola Hernandez, Dominic E Dwyer, Jen Kok, Alvaro Borges, Christian T Brandt, Lene S Knudsen, Nikolaos Sypsas, Costas Constantinou, Antonios Markogiannakis, Spyros Zakynthinos, Paraskevi Katsaounou, Ioannis Kalomenidis, Analia Mykietiuk, Maria F Alzogaray, Mora Obed, Laura M Macias, Juan Ebensrtejin, Patricia Burgoa, Esteban Nannini, Matias Lahitte, Santiago Perez-Patrigeon, José Arturo Martínez-Orozco, Juan Pablo Ramírez- Hinojosa Richard T Davey, MD, Prof Eduardo Fernández-Cruz, MD, Prof Norman Markowitz, MD, Sarah Pett, MBBS, Prof Abdel G Babiker, PhD, Deborah Wentworth, MPh, Surender Khurana, PhD, Nicole Engen, MSc, Prof Fred Gordin, MD, Prof Mamta K Jain, MD, Prof Virginia Kan, MD, Mark N Polizzotto, MBBS, Paul Riska, MD, Prof Kiat Ruxrungtham, MD, Prof Zelalem Temesgen, MD, Prof Jens Lundgren, MD, John H Beigel, MD, H Clifford Lane, MD, Prof James D Neaton, PhD Richard T Davey, Eduardo Fernández-Cruz, Norman Markowitz, Sarah Pett, Abdel G Babiker, Deborah Wentworth, Surender Khurana, Nicole Engen, Fred Gordin, Mamta K Jain, Virginia Kan, Mark N Polizzotto, Paul Riska, Kiat Ruxrungtham, Zelalem Temesgen, Jens Lundgren, John H Beigel, H Clifford Lane, James D Neaton, Jessica Butts, Eileen Denning, Alain DuChene, Eric Krum, Merrie Harrison, Sue Meger, Ross Peterson, Kien Quan, Megan Shaughnessy, Greg Thompson, David Vock, Julia Metcalf, Robin Dewar, Tauseef Rehman, Ven Natarajan, Rose McConnell, Emily Flowers, Kenny Smith, Marie Hoover, Elizabeth M Coyle, David Munroe, Bitten Aagaard, Mary Pearson, Adam Cursley, Helen Webb, Fleur Hudson, Charlotte Russell, Aminata Sy, Cara Purvis, Brooke Jackson, Yolanda Collaco-Moraes, Dianne Carey, Rosemary Robson, Adriana Sánchez, Elizabeth Finley, Donna Conwell, Marcelo H Losso, Luciana Gambardella, Cecilia Abela, Paco Lopez, Helena Alonso, Giota Touloumi, Vicky Gioukari, Olga Anagnostou, Anchalee Avihingsanon, Kanitta Pussadee, Sasiwimol Ubolyam, Bola Omotosho, Clemencia Solórzano, Tianna Petersen, Kranthi Vysyaraju, Stacey A Rizza, Jennifer A Whitaker, Raquel Nahra, John Baxter, Patricia Coburn, Edward M Gardner, James A Scott, Leslie Faber, Erica Pastor, Linda Makohon, Rodger A MacArthur, L Monique Hillman, Marti J Farrough, Hari M Polenakovik, Linda A Clark, Roberto J Colon, Ken M Kunisaki, Miranda DeConcini, Susan A Johnson, Cameron R Wolfe, Laura Mkumba, June Y Carbonneau, Alison Morris, Meghan E Fitzpatrick, Cathy J Kessinger, Robert A Salata, Karen A Arters, Catherine M Tasi, Ralph J Panos, Laura A Lach, Marshall J Glesby, Kirsis A Ham, Valery G Hughes, Robert T Schooley, Daniel Crouch, Leticia Muttera, Richard M Novak, Susan C Bleasdale, Ariel E Zuckerman, Weerawat Manosuthi, Supeda Thaonyen, Thaniya Chiewcharn, Gompol Suwanpimolkul, Sivaporn Gatechumpol, Sirikunya Bunpasang, Brian J Angus, Monique Anderson, Marcus Morgan, Jane Minton, Maria N Gkamaletsou, Joe Hambleton, David A Price, Martin J Llewelyn, Jonathan Sweetman, Javier Carbone, Jose R Arribas, Rocio Montejano, Jose L Lobo Beristain, Iñaki Z Martinez, Jose Barberan, Paola Hernandez, Dominic E Dwyer, Jen Kok, Alvaro Borges, Christian T Brandt, Lene S Knudsen, Nikolaos Sypsas, Costas Constantinou, Antonios Markogiannakis, Spyros Zakynthinos, Paraskevi Katsaounou, Ioannis Kalomenidis, Analia Mykietiuk, Maria F Alzogaray, Mora Obed, Laura M Macias, Juan Ebensrtejin, Patricia Burgoa, Esteban Nannini, Matias Lahitte, Santiago Perez-Patrigeon, José Arturo Martínez-Orozco, Juan Pablo Ramírez- Hinojosa 
The Lancet Respiratory Medicine 
DOI: /S (19)30253-X
Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

2. Figure 1 FLU-IVIG trial profile
hIVIG=hyperimmune intravenous immunoglobulin.
The Lancet Respiratory Medicine DOI: ( /S (19)30253-X)
Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

3. Figure 2
Proportional distribution of primary endpoint categories at day 7 of follow-up for patients infected with influenza A and B
(A) Proportions have been calculated from day-7 data for 111 patients in the hIVIG group and 110 in the placebo group. The OR estimate includes imputed data for three additional patients in the hIVIG group (n=114); these patients were discharged before day 7 and the imputation was on whether normal activities had been resumed. (B) Proportions have been calculated from day-7 data for 41 patients in the hIVIG and in the 42 placebo group. The OR estimate includes imputed data for one additional patient in the hIVIG group (n=42); this patient was discharged before day 7 and the imputation was on whether normal activities had been resumed. hIVIG=hyperimmune intravenous immunoglobulin. ICU=intensive care unit. OR=odds ratio.
The Lancet Respiratory Medicine DOI: ( /S (19)30253-X)
Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

4. Figure 3
Haemagglutination inhibition titres by reference virus and treatment group
Patients infected with influenza A(H1N1) with (A) A/California/07/2009 or (B) A/Michigan/45/2015 used as the reference virus for analysis. Patients infected with influenza A(H3N2) with (C) A/Hong Kong/4801/2014 or (D) A/Switzerland/2013/50/2012 used as the reference virus for analysis. Patients infected with influenza B with (E) B/Brisbane/60/2008 or (F) B/Phuket/3073/2013 used as the reference virus for analysis. hIVIG=hyperimmune intravenous immunoglobulin.
The Lancet Respiratory Medicine DOI: ( /S (19)30253-X)
Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

5. Figure 4
Antibody affinity of hIVIG to properly folded haemagglutinin of seasonal influenza vaccine strains in SPR analysis
Sequential SPR analysis of human hIVIG was done against properly folded homologous haemagglutinin from the H1N1pdm09, H3N2, and B influenza vaccine strains for each lot of hIVIG used. 50-fold, 100-fold, and 200-fold dilutions of individual hIVIG lots were evaluated. Antibody off-rate constants that describe the fraction of antibody-antigen complexes decaying per second were determined directly from the hIVIG interaction with each of the three haemagglutinin proteins using SPR in the dissociation phase (appendix p 7). Slower dissociation kinetics (off-rate) of antigen-antibody complex means higher antibody affinity. hIVIG=hyperimmune intravenous immunoglobulin. SPR=surface plasmon resonance.
The Lancet Respiratory Medicine DOI: ( /S (19)30253-X)
Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

6. Figure 5
Change in overall and serotype-specific nasopharyngeal viral load
Analyses only include participants with detectable viral load at baseline and are adjusted for baseline viral load and geographical region. The overall analysis was also adjusted for influenza subtype. *Excludes five participants with unknown serotype. †Excludes three participants with unknown lineage.
The Lancet Respiratory Medicine DOI: ( /S (19)30253-X)
Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions