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The benefits: exercise and cardiometabolic disease

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Presentation on theme: "The benefits: exercise and cardiometabolic disease"— Presentation transcript:

1 The benefits: exercise and cardiometabolic disease
Dominique Hansen, PhD, FESC

2 Faculty Disclosure The presenter has advised that the following presentation will NOT include discussion on any commercial products or service and that there are NO financial interests or relationships with any of the Commercial Supporters of this years ASM.

3 Exercise in cardiovascular disease: guidelines
Piepoli MF, et al. Eur J Prev Cardiol 2016;23:NP1-96

4 But do we follow and implement these guidelines?

5 Do we adhere to the guidelines?

6 Do we adhere to the guidelines?

7 Do we adhere to the guidelines?

8 Physical activity in healthy people: why?

9 Physical activity in healthy people: why?

10 Physical activity in healthy people: why?
149,077 participants over an 8.9-year (median) follow-up

11 Seven days of bed rest in healthy individuals leads to:
1.4 kg muscle mass loss 7% reduction in muscle strength 8% reduction in skeletal muscle oxidative capacity 6% reduction in VO2peak 29% reduction in insulin sensitivity Dirks M, et al. Diabetes. 2016; 65:

12 Physical activity in people with cardiometabolic disease: why?

13 Importance of CVD risk factor management

14 Role of exercise in hypertension

15 Role of exercise in hypertension

16 Role of exercise in dyslipidaemia

17 But patient phenotype matters…

18 And statin intake matters…

19 Role of exercise in obesity

20 What is then the role of exercise in obesity?
Ross R, et al J Appl Physiol 1996; 81: 20

21 What is then the role of exercise in obesity?
Duration of endurance exercise Mittendorfer B, et al. Am J Physiol 2004; 286: E354 21

22 What is then the role of exercise in obesity?

23 What is then the role of exercise in obesity?
Larson-Meyer DE, et al. Med Sci Sports Exerc 2010; 42: 152 23

24 What is then the role of exercise in obesity?
Ross R, et al J Appl Physiol 1996; 81:

25 What is then the role of exercise in obesity?

26 What is then the role of exercise in obesity?
fatness vs fitness

27 Role of exercise in type 2 diabetes

28 Role of exercise in type 2 diabetes
Umpierre D, et al. JAMA 2011; 305:

29 Role of exercise in type 1 diabetes

30 Imp act on glycaemic variability?

31 Imp act on glycaemic variability?

32 Role of exercise in deconditioning

33 Role of exercise in deconditioning
Dependency

34 Role of exercise in deconditioning

35 Economic impact of exercise

36 Role of exercise in coronary artery disease

37 Role of exercise in coronary artery disease

38 Role of exercise in coronary artery disease

39 Role of exercise in coronary artery disease

40 Role of exercise in heart failure

41 Role of exercise in heart failure

42 Role of exercise in heart failure

43 Role of exercise in heart failure

44 Role of exercise in heart failure

45 Role of exercise in heart failure

46 Conclusions Exercise intervention is potent to improve CVD risk, and lead to better treatment of cardiometabolic disease However, current gaps in knowledge should be addressed and clinicians must be aware of what exercise is not capable of doing (yet)

47 https://twitter.com/hansen_phd
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