1. « Poultry HPAI Vaccination: Decision Making »
Dr Christianne Bruschke
Scientific and Technical Department
« Poultry HPAI Vaccination: Decision Making »
Comments (with copyright) / Commentaires (soumis au Copyright) :
GDLN seminar
Paris, 19 March 2008

2. Documents on HPAI Vaccination
OIE Code
Chapter : Avian Influenza
OIE Terrestrial Manual:
Chapter I.1.7: Principles of Vet. Vaccine Production
Chapter : Highly Pathogenic Avian Influenza
In Collaboration with FAO:
OIE information document on avian influenza vaccination (March 2006)
OIE guidelines on vaccination against HPAI (May 2007)
Other documents:
The FAO/ OIE global strategy and the FAO recommendations on AI in Asia (sept 2004)

3. Guidelines on the implementation of AI Vaccination
To guide countries in their decision making on
the implementation of eradication strategies including vaccination
To establish detailed guidelines and a checklist for the application, monitoring, precautionary measures of vaccination strategies

4. Strategy from Beginning: To Minimize Threat at Animal Source
Early detection and early warning
Rapid and transparent notification
Rapid confirmation of suspects
Rapid response
use of vaccination when available and if appropriate

5. Vaccination Induction of immune response
Protection against morbidity, mortality and decline of egg production
Higher resistance to infection
Decrease of virus shedding
Reduction of spread between birds and flocks
Vaccination should always be complemented by other measures like increase biosecurity, movement controls and stamping out

6. Analysis before Vaccination decision
National regulations
Local epidemiological situation
Zoo-technical aspects
Socio-economic aspects
Capacity of the Veterinary Services
Financial situation
Availability of sufficient high quality vaccine
Trade implications

7. Local epidemiological situation
Knowledge of the outcome surveillance system
Status neighboring countries
Status trade partners
Presence of legal or illegal international trade
Presence of live bird markets
Infection status wild birds
Human health implications

8. Zoo -technical aspects
Poultry production systems in place (sectors 1-4)
Poultry species reared
Multi age system
Biosecurity levels
Sources of feed and water
Poultry workers and husbandry practices

9. Socio-Economic Factors
Culture
Public Acceptance
Compensation schedules
Food security aspects
Small holders livelihoods
Financial aspects of eradication

10. Vaccination Strategy Emergency in the face of an epidemic
Preventive when high risk of incursion and insufficient response measures
Routine in an endemic situation
Mass vaccination: all susceptible poultry are vaccinated
Targeted vaccination: defined categories of birds are vaccinated

11. Vaccine strain Choice of the vaccine strain
Homologous or Heterologous
Monovalent or Bivalent
Recombinant
Vaccine production according to OIE standards to assure high quality

12. Principles of Veterinary Vaccine Production
Quality Assurance
Efficacy and Safety tests
Stability
Batch Control
Field tests
Production facilities
Etc
Specific requirements for HPAI vaccines in chapter on highly pathogenic avian influenza

13. World organisation for animal health
12 rue de Prony
75017 Paris, France
Tel: 33 (0)
Fax: 33 (0)