1. Evidence-based management of bronchiolitis.
Evidence-based management of bronchiolitis. Passive prophylaxis is a safe and effective way of protecting infants at risk for severe respiratory syncytial virus (RSV) disease but is not cost-efficient. Once the infection is established, the mainstay of current therapy remains supportive care because no solid scientific evidence supporting the use of any conventional or experimental pharmacologic agent currently exists. For the future, promising antiviral molecules and new-generation humanized monoclonal antibodies are being investigated, and structural biology may overcome the challenges that have so far prevented the development of a safe and effective RSV vaccine.
Giovanni Piedimonte, and Miriam K. Perez Pediatrics in Review 2014;35:
©2014 by American Academy of Pediatrics