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Structural organization of ALK and its fusion proteins.

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Presentation on theme: "Structural organization of ALK and its fusion proteins."— Presentation transcript:

1 Structural organization of ALK and its fusion proteins.
Structural organization of ALK and its fusion proteins. ALK is a receptor-type PTK with a single transmembrane (TM) domain as well as 2 MAM domains and a putative ligand-binding (LB) domain in the extracellular region. The intracellular region contains a kinase domain and is fused to EML4 in NSCLCs, to NPM1 in ALCLs, to TPM3 in IMTs, and to VCL in RMCs. Hiroyuki Mano Cancer Discovery 2012;2: ©2012 by American Association for Cancer Research

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