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Figure 1 EDSS score (A), T2LV (B) and T1LV (C) courses in patients who experienced WNS after FTY withdrawal EDSS score (A), T2LV (B) and T1LV (C) courses.

Published byFrancesco Manfredi Modified over 4 years ago

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Presentation on theme: "Figure 1 EDSS score (A), T2LV (B) and T1LV (C) courses in patients who experienced WNS after FTY withdrawal EDSS score (A), T2LV (B) and T1LV (C) courses."— Presentation transcript:

1 Figure 1 EDSS score (A), T2LV (B) and T1LV (C) courses in patients who experienced WNS after FTY withdrawal EDSS score (A), T2LV (B) and T1LV (C) courses in patients who experienced WNS after FTY withdrawal (A) EDSS scores were reported at FTY stop, WNS and 2-year follow-up. Patients with δEDSS-ratio ≥ 2 reached very high EDSS scores at WNS and accumulated more disability at 2-year follow-up when compared to patients with >1 δEDSS-ratio >2. (B) T2LV was calculated at FTY stop, WNS and 6-month FU. At the 6-month follow-up, all patients and particularly those with δEDSS-ratio ≥ 2, had a T2LV increase compared to the pre-FTY suspension MRI, although decreased with respect to the MRI scan at WNS, likely due to the resolution of a portion of T2 hyperintensity, probably reflecting oedema. (C) T1LV was calculated at FTY stop and 6-month FU to consider chronic black holes. At 6-month follow-up all patients, and particularly those with δEDSS-ratio ≥ 2, showed a T1LV increase with respect to the MRI scan at WNS. EDSS = expanded disability status scale; FTY = fingolimod; FU = follow-up; T1LV = T1 lesion volume; T2LV = T2 lesion volume; WNS = worsening of neurologic status; δEDSS-ratio = post-FTY withdrawal δEDSS/pre-FTY withdrawal δEDSS ratio. Caterina Lapucci et al. Neurol Neuroimmunol Neuroinflamm 2019;6:e566 Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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