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Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats  Shen-Kou Tsai, MD, PhD, Li-Man Hung, PhD,

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Presentation on theme: "Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats  Shen-Kou Tsai, MD, PhD, Li-Man Hung, PhD,"— Presentation transcript:

1 Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats  Shen-Kou Tsai, MD, PhD, Li-Man Hung, PhD, Yuan-Tsung Fu, MD, Henrich Cheng, MD, PhD, Mao-Wei Nien, Hsin-Yi Liu, BS, Friedrich Bo-Yuan Zhang, BS, Shiang-Suo Huang, PhD  Journal of Vascular Surgery  Volume 46, Issue 2, Pages (August 2007) DOI: /j.jvs Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Western blot analyses of brain tissue after FCI injury for iNOS, eNOS, nNOS, and β-actin in rats. Rats were treated with vehicle or resveratrol at a dose of 1 μg/kg when the common carotid arteries clips were removed. Data were normalized with β-actin and expressed as percentage rate. Each value represents the mean of seven individual experiments. Results are expressed as mean ± SEM. *P < .05 compared with vehicle group. S = sham group, non-ischemic operated rats; V = vehicle-treated group; R = resveratrol-treated group. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Analysis of iNOS, eNOS, nNOS, and β-actin mRNA expression of brain tissue in rats after FCI injury. Rats were treated with vehicle or resveratrol at a dose of 1 μg/kg when the common carotid arteries clips were removed. S = sham group, non-ischemic operated rats; V = vehicle-treated group; R = resveratrol-treated group. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Effect of resveratrol in the levels of MDA on FCI injury rats. Each experimental group is seven rats. Values are expressed as mean ± SEM. *P < .05 compared with vehicle group. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 Effect of NOS inhibitors on the neuroprotective effect of resveratrol in FCI injury rats. Each experimental group is seven rats. Values are expressed as mean ± SEM. *P < .05 compared with vehicle group. #P < .05 compared with resveratrol group. L-NAME (1 mg/kg; i.v.): nonselective NOS inhibitor. 7-nitroindazole (50 mg/kg; i.p.): nNOS selective inhibitor. S-methylisothiourea: (3 mg/kg; i.p.): iNOS selective inhibitor. L-NIO (10 mg/kg; i.p.): eNOS selective inhibitor. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

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