1. White Matter by Diffusion MRI following Methylphenidate Treatment: A Randomized Control Trial in Males with Attention-Deficit/Hyperactivity Disorder
In boys with attention-deficit/hyperactivity disorder (ADHD), 4 months of treatment with methylphenidate (MPH) was associated with increased white matter fractional anisotropy (FA) after 16 weeks.
In adult men with ADHD and both boys and adult men receiving placebo, changes in FA measures were not present, suggesting that the effects of methylphenidate on brain white matter are modulated by age.
Voxel-wise FA maps show areas where difference between baseline and posttreatment in children treated with MPH is higher than in adults treated with MPH (color coded orange) (P < .05).
Bouziane C et al. Published Online: August 13, 2019