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High-throughput drug screen (HTDS) reveals ARS1620 and PI3K pathway inhibitors synergies and a heterogeneous pattern of RTK synergies. High-throughput.

Published byRudolf Tóth Modified over 4 years ago

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Presentation on theme: "High-throughput drug screen (HTDS) reveals ARS1620 and PI3K pathway inhibitors synergies and a heterogeneous pattern of RTK synergies. High-throughput."— Presentation transcript:

1 High-throughput drug screen (HTDS) reveals ARS1620 and PI3K pathway inhibitors synergies and a heterogeneous pattern of RTK synergies. High-throughput drug screen (HTDS) reveals ARS1620 and PI3K pathway inhibitors synergies and a heterogeneous pattern of RTK synergies. A, Pie chart of 112 drugs: color code corresponds to hit target type. B, Top hits identified across 112 drugs tested in combination with ARS1620. Only combinations yielding at least 1 instance of a 5-fold shift in IC50 in the presence of ARS1620 over single agent are presented. C, Pattern of a selected panel of recurrent effective combination across cell lines. IC50 shift (median across biological replicates) is shown. Sandra Misale et al. Clin Cancer Res 2019;25: ©2019 by American Association for Cancer Research

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