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Thoracoscopic Versus Thoracotomy Approaches to Lobectomy: Differential Impairment of Cellular Immunity  Bryan A. Whitson, MD, PhD, Jonathan D'Cunha, MD,

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Presentation on theme: "Thoracoscopic Versus Thoracotomy Approaches to Lobectomy: Differential Impairment of Cellular Immunity  Bryan A. Whitson, MD, PhD, Jonathan D'Cunha, MD,"— Presentation transcript:

1 Thoracoscopic Versus Thoracotomy Approaches to Lobectomy: Differential Impairment of Cellular Immunity  Bryan A. Whitson, MD, PhD, Jonathan D'Cunha, MD, PhD, Rafael S. Andrade, MD, Rosemary F. Kelly, MD, Shawn S. Groth, MD, Baolin Wu, PhD, Jeffrey S. Miller, MD, Robert A. Kratzke, MD, Michael A. Maddaus, MD  The Annals of Thoracic Surgery  Volume 86, Issue 6, Pages (December 2008) DOI: /j.athoracsur Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Flow cytometry analysis of the phenotype of the peripheral blood mononuclear cells perioperatively. (A) Cytotoxic (CD3+/CD8+) and helper (CD3+/CD4+) T-cell subsets. (B) CD4/CD8 ratio. (OT = open thoracotomy; POD = postoperative day; PREOP = preoperatively; VATS = video-assisted thoracoscopic surgery.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Cellular cytotoxicity. (A) Percent specific lysis. (B) Normalized (to postoperative day [POD] 0) percent specific lysis. (OT = open thoracotomy; PREOP = preoperatively; VATS = video-assisted thoracoscopic surgery.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Gene signature validation. (RT-PCR = reverse-transcriptase polymerase chain reaction; VATS = video-assisted thoracoscopic surgery.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Protein validation of gene expression. (A) Matrix metalloproteinase 9 concentrations. (B) Insulin-like growth factor binding protein 3 concentrations. (OT = open thoracotomy; POD = postoperative day; PREOP = preoperatively; VATS = video-assisted thoracoscopic surgery.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions


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