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Dual blockade of PD-1 and CTLA-4 directly activates CD4+Foxp3− cells in the absence of CD8+ or CD4+Foxp3+ cells. Dual blockade of PD-1 and CTLA-4 directly.

Published byAmélie Guertin Modified over 4 years ago

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Presentation on theme: "Dual blockade of PD-1 and CTLA-4 directly activates CD4+Foxp3− cells in the absence of CD8+ or CD4+Foxp3+ cells. Dual blockade of PD-1 and CTLA-4 directly."— Presentation transcript:

1 Dual blockade of PD-1 and CTLA-4 directly activates CD4+Foxp3− cells in the absence of CD8+ or CD4+Foxp3+ cells. Dual blockade of PD-1 and CTLA-4 directly activates CD4+Foxp3− cells in the absence of CD8+ or CD4+Foxp3+ cells. A–C, C57BL/6 WT or D–F. DEREG mice were injected s.c. with 5 × 105 AT-3ovadim CD73+ tumor cells. Mice were treated with 2A3 or anti–PD-1 and anti–CTLA-4 as per Fig. 2. On days 13, 14, and 18, mice were treated where indicated with anti-CD8 (250 μg/mouse) and/or diphtheria toxin (DT; 0.5 μg/mouse). On day 21, leukocytes were isolated from tumors (TILs) or DLNs and analyzed by flow cytometry. The expression of (A, D) Tbet, (B, E) CD62L, and (C, F) IFNγ by CD4+Foxp3− cells was determined. Data shown as the mean ± SEM of 3–13 mice per group. *, P < 0.05; **, P < 0.01; ***, P < 0.001; n.s., not significant (one-way ANOVA/Tukey). Paul A. Beavis et al. Cancer Immunol Res 2018;6: ©2018 by American Association for Cancer Research

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