1. Morphologic examination of presynapse and postsynapse in smn-1 mutant animals.
Morphologic examination of presynapse and postsynapse in smn-1 mutant animals. A, top, Confocal images of GFP expression in the presynaptic terminal of GABAergic motor neurons [synaptobrevin::GFP driven by unc-25 (GAD) promoter] in L2 and Late (L2 + 3 d) animals (four genotypes: N2, smn-1(ok355), daf-2(e1370) and smn-1(ok355);daf-2(e1370)). Bottom, Confocal images of GFP expression in postsynaptic GABAergic neuromuscular synapses [UNC-49::GFP driven by unc-49 (GABA receptor) promoter] in L2 and Late (L2 + 3 d) animals. All images were obtained from same region of dorsal nerve cord of the C. elegans strains and each line of puncta images are derived from a single animal as a spatial raster plot.
Chia-Yen Wu et al. eNeuro 2018;5:ENEURO
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