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Epigenome Sequencing Comes of Age

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1 Epigenome Sequencing Comes of Age
Jian-Kang Zhu  Cell  Volume 133, Issue 3, Pages (May 2008) DOI: /j.cell Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 DNA Methyltransferases and Demethylases in Arabidopsis
DNA methyltransferases can be targeted by both small RNA-dependent and RNA-independent pathways to achieve methylation at CG or non-CG sites. For some loci, DNA demethylases actively remove methylation to prevent silencing. Small RNA production is controlled by DNA methylation in a self-reinforcing positive feedback loop. The dotted line indicates the possibility that small RNAs may direct heterochromatic histone modifications. Cell  , DOI: ( /j.cell ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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