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In vivo thrombosis of tumor vasculature.

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Presentation on theme: "In vivo thrombosis of tumor vasculature."— Presentation transcript:

1 In vivo thrombosis of tumor vasculature.
In vivo thrombosis of tumor vasculature. Administration of the thrombogen caused thrombosis in tumor vasculature but not in normal organs. A, tumor containing thrombotic vessels caused by integrin targeting thrombogen (vessels are indicated by yellow arrowheads, ×40). B, a control tumor treated with TF1-218 (vessels are indicated by arrows, ×40). C, quantitative analysis of thrombosed vessels in Fn-TF3-218 treated (n = 6) versus control TF1-218 treated (n = 6) tumors (magnification at ×40, P < 0.001). D to F, representative immunohistochemical analysis of thrombosed tumors with anti-CD31 antibody (red), anti-human TF antibody (green), and the merged image of D and E, respectively. G to L, representative Carstair staining of organ sections from FN-TF3-218 treated tumor-bearing mice from liver, heart, brain, muscle, kidney, and lung, respectively (×40). Cheng Liu et al. Mol Cancer Ther 2004;3: ©2004 by American Association for Cancer Research

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