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TNF-Inhibition with Etanercept for Graft-versus-Host Disease Prevention in High-Risk HCT: Lower TNFR1 Levels Correlate with Better Outcomes  Sung W. Choi,

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Presentation on theme: "TNF-Inhibition with Etanercept for Graft-versus-Host Disease Prevention in High-Risk HCT: Lower TNFR1 Levels Correlate with Better Outcomes  Sung W. Choi,"— Presentation transcript:

1 TNF-Inhibition with Etanercept for Graft-versus-Host Disease Prevention in High-Risk HCT: Lower TNFR1 Levels Correlate with Better Outcomes  Sung W. Choi, Patrick Stiff, Kenneth Cooke, James L.M. Ferrara, Thomas Braun, Carrie Kitko, Pavan Reddy, Gregory Yanik, Shin Mineishi, Sophie Paczesny, David Hanauer, Attaphol Pawarode, Edward Peres, Tulio Rodriguez, Scott Smith, John E. Levine  Biology of Blood and Marrow Transplantation  Volume 18, Issue 10, Pages (October 2012) DOI: /j.bbmt Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Day +7 tumor necrosis factor receptor 1 (TNFR1) ratio. (A) The median day +7 TNFR1 ratio of 1.34 in our study population (, N = 100) was significantly lower than the ratio of 1.84 observed in our previous study (, N = 161), P < (B) Patients who received a non–total body irradiation (non-TBI)-containing regimen (, N = 71) experienced a significantly low day +7 ratio of 1.10 compared to 1.89 in patients who received a TBI-based conditioning regimen (, N = 29), P < .001. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Cumulative incidence of acute graft-versus-host disease (aGVHD). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 One-year non-relapse mortality and overall survival. Non–total body irradiation (TBI) (, N = 71) versus TBI (- - -, N = 29). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

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