1. Central Trpm8GFP axons terminate in superficial lamina of the spinal cord dorsal horn. a, GFP fluorescence reveals central axons of Trpm8GFP neurons in the dorsal horn of Trpm8GFP mouse spinal cords. b, c, Immunostaining with anti-GFP antibodies shows GFP a...
Central Trpm8GFP axons terminate in superficial lamina of the spinal cord dorsal horn. a, GFP fluorescence reveals central axons of Trpm8GFP neurons in the dorsal horn of Trpm8GFP mouse spinal cords. b, c, Immunostaining with anti-GFP antibodies shows GFP axons in both sacral (b) and lumbar regions (c) of the superficial spinal cord dorsal horn. Arrowheads illustrate the presence of Trpm8GFP projections deeper in the dorsal horn. d, Trpm8GFP axons and CGRP-immunoreactive axons terminate in the same lamina of the spinal cord. e, g, Trpm8GFP axon terminals do not overlap with those that bind IB4 (e) or with interneurons that are immunoreactive for PKCγ (g). f, Closer examination reveals that there is little overlap of Trpm8GFP fibers and those that bind IB4, indicating distinct central terminals for each fiber type.
Yoshio Takashima et al. J. Neurosci. 2007;27:
©2007 by Society for Neuroscience