1. Progress Seminar
권순빈

2. 연구 진행 상황 보고서 2주전 계획 연구 결과 문제점 및 대책 목표 및 계획 CPF 정형외과 낙상 혈당센서 논문 제출 IRB
논문 초안
요청사항 완료
문제점 및 대책
목표 및 계획

3. Mechanism of Electrical Stimulation for pain relief
Pain Mechanism : A New Theory
Gate Control Theory
Melzack and Wall in 1965
McGill & MIT; Science
A gate control system modulates sensory input from the skin before it evokes pain perception and response

4. Mechanism of Electrical Stimulation for pain relief
There are three types of nerve fibers  A, B, C
Four subgroups of A fibers  A-alpha, A-beta, A-gamma and A-delta
A-delta and C  smaller & carries pain
Other A fibers  larger & carries pressure, temperature, touch, etc.
Pain pathway
A-delta & C fibers are activated
Go through spinal cord and to the brain
 But this is not true!

5. Mechanism of Electrical Stimulation for pain relief
There is a gate control system at the spinal cord
Substantia gelatinosa (SG) determines which signal to reach the T cells
L (Large fibers) and S (Small fibers)
If ‘S’ < ‘L’
SG prevents the transmission of the pain to T cells
Other sensory signal override the pain signal
Pain signal is not reached to the brain
 If ‘S’ > ‘L’
Pain signal transmitted to T cell and to the brain
Descending signal from CNS also affects the decision of the gate

6. Mechanism of Electrical Stimulation for pain relief
Transcutaneous Electric Nerve Stimulation (TENS)
Segmental (Stimulating the ‘L’ fibers )
Only large-diameter primary afferent fibers from deep tissue are activated at sensory intensities up to & including motor threshold
Descending (Activates the adrenergic & opioids receptors)
Mechanism not found yet
Block specific receptor or pathway & sees the effect