1. Outcomes
Group
Number
of events
Total
person-years
aIRR (95%CI)
Forest plot
DPP-4Is vs BGs
Primary Outcomes MI
BGs
609.0
909,479.0
1 [Reference]
DPP-4Is
1,046.0
1,070,551.6
1.46[ ] HF
3,260.5
957,259.3
5,499
1,127,507.4
1.43( )
Stroke
101.9
958,792.0
116
1,130,832.0
0.96( )
Secondary Outcome
Composite CVDs
4,149.4
907,963.0
6,879.0
1,067,098.6
1.41[ ]
DPP-4Is vs SUs
SUs
1,004.1
801,475.1
1,096.0
1,088,170.6
0.80[ ]
5,755.0
835,978.0
6,485
1,144,086.5
0.82( )
123.7
838,028.2
129
1,147,890.8
0.76( )
7,031.6
799,350.8
7,918.0
1,084,259.1
0.83[ ]
DPP-4Is vs α-GIs
α-GIs
842.6
769,739.4
1,108.0
1,101,155.6
0.92[ ]
4,412.8
805,723
6,689
1,158,361.5
1.05( )
108.1
807,552.9
131
1,162,238.5
0.84( )
5,370.0
767,968.0
8,145.0
1,097,179.4
1.06[ ]
0.5
1.0
aIRR
1.5
2.0
Figure S1. Adjusted incidence rate ratio assessing the association between DPP-4Is and cardiovascular risks in each pseudopopulation.