Presentation is loading. Please wait.

Presentation is loading. Please wait.

Glycerophospholipids and related metabolites are differentially expressed in sera from patients with RA before (A) and after (B) treatment with rituximab.

Published byIstván Pap Modified over 4 years ago

Similar presentations

Presentation on theme: "Glycerophospholipids and related metabolites are differentially expressed in sera from patients with RA before (A) and after (B) treatment with rituximab."— Presentation transcript:

1 Glycerophospholipids and related metabolites are differentially expressed in sera from patients with RA before (A) and after (B) treatment with rituximab. Glycerophospholipids and related metabolites are differentially expressed in sera from patients with RA before (A) and after (B) treatment with rituximab. Pathway map connects related classes of compounds based on biological activity. Blue indicates classes that are downregulated in responders, red indicates classes that are upregulated in responders, yellow is no significant difference and light blue indicates not detected. Split boxes represent standard ester linkage glycerophospholipids on the top and alkyl ethers on the bottom. CDP, cytidine diphosphate; CDP-Etn, CDP-ethanolamine; Etn-P, phosphoethanolamine; PA, phosphatidic acids; PC, phosphatidylcholines; PE, phosphatidylethanolamines; PEM1, phosphatidyl-N-monomethylethanolamine 1; PEM2, phosphatidyl-N-monomethylethanolamine 2; PG, phosphatidylglycerols; PM1, phosphatidyl monomethylethanolamine; PS, phosphatidylserines; TCA, tricarboxylic acid. Shannon R Sweeney et al. RMD Open 2016;2:e000289 Copyright © BMJ Publishing Group & EULAR. All rights reserved.

Download ppt "Glycerophospholipids and related metabolites are differentially expressed in sera from patients with RA before (A) and after (B) treatment with rituximab."

Similar presentations

Triacylglycerol Synthesis

Triacylglycerol Synthesis
A b b a a a a a a c a a b a a b a,b a,c a B c b,c a a,c a,c c a b,c b

A b b a a a a a a c a a b a a b a,b a,c a B c b,c a a,c a,c c a b,c b
Summary of TB cases across indications and trial periods

Summary of TB cases across indications and trial periods
Change in mean extent of lung tissue and lung tissue with ground glass or reticular pattern involvement from baseline to 12 months follow-up in patients.

Change in mean extent of lung tissue and lung tissue with ground glass or reticular pattern involvement from baseline to 12 months follow-up in patients.
Multivariable model of abatacept retention in biologic-naïve patients.

Multivariable model of abatacept retention in biologic-naïve patients.
Volume 24, Issue 3, Pages (July 2018)

Volume 24, Issue 3, Pages (July 2018)
Persistence of first tumour necrosis factor alpha inhibitor (TNFi) by TNFi Kaplan-Meier plot of time (years) to discontinuation of treatment by TNFi. (A)

Persistence of first tumour necrosis factor alpha inhibitor (TNFi) by TNFi Kaplan-Meier plot of time (years) to discontinuation of treatment by TNFi. (A)
Multivariable model of abatacept retention by RF and anti-CCP status in biologic-naïve patients with or without radiographic erosion at baseline. Multivariable.

Multivariable model of abatacept retention by RF and anti-CCP status in biologic-naïve patients with or without radiographic erosion at baseline. Multivariable.
Flow chart of the steps in the EMEUNET Peer Review Mentoring Program.

Flow chart of the steps in the EMEUNET Peer Review Mentoring Program.
Naïve B cells (CD19+CD27-), memory B cells (CD19+CD27+) and plasmablasts (PB CD27++) levels in patients with systemic sclerosis. Indicated points resemble.

Naïve B cells (CD19+CD27-), memory B cells (CD19+CD27+) and plasmablasts (PB CD27++) levels in patients with systemic sclerosis. Indicated points resemble.
Immunohistochemical (IHC) staining for CD117 on synovial tissue (ST) of patients with inflammatory bowel disease (IBD) with onset of peripheral arthritis.

Immunohistochemical (IHC) staining for CD117 on synovial tissue (ST) of patients with inflammatory bowel disease (IBD) with onset of peripheral arthritis.
Analysis of changes in the host metabolome during M

Analysis of changes in the host metabolome during M
Lipid biosynthesis. Lipid biosynthesis. Schematic overview of the pathways involved in the synthesis of fatty acids (FAs), cholesterol, phosphoglycerides,

Lipid biosynthesis. Lipid biosynthesis. Schematic overview of the pathways involved in the synthesis of fatty acids (FAs), cholesterol, phosphoglycerides,
Kaplan-Meier survival plots for survival without: (A) progression to RA according to the number of joints with significant synovitis defined by GS≥ grade.

Kaplan-Meier survival plots for survival without: (A) progression to RA according to the number of joints with significant synovitis defined by GS≥ grade.
Percentage of patients achieving EULAR response

Percentage of patients achieving EULAR response
ASAS 20/40 response rates, and mean change from baseline in BASDAI through week 156* of treatment. *For patients who discontinued, the end of treatment.

ASAS 20/40 response rates, and mean change from baseline in BASDAI through week 156* of treatment. *For patients who discontinued, the end of treatment.
Endochondral bone formation in HLA-B27 transduced ATDC5 micromasses.

Endochondral bone formation in HLA-B27 transduced ATDC5 micromasses.
Flow diagram of the literature search process, including exclusions and reasons for exclusions. *Population of pregnant women (n=2), asymptomatic antiphospholipid.

Flow diagram of the literature search process, including exclusions and reasons for exclusions. *Population of pregnant women (n=2), asymptomatic antiphospholipid.
PPD status of CZP-treated patients with RA in the pooled RA safety database (N=4049) at baseline and TB incidence by INH treatment. †One patient who developed.

PPD status of CZP-treated patients with RA in the pooled RA safety database (N=4049) at baseline and TB incidence by INH treatment. †One patient who developed.
Figure 5 Ether-containing lipid biosynthesis pathways

Figure 5 Ether-containing lipid biosynthesis pathways

Similar presentations

Ads by Google