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Innate immune defects correlate with failure of antibody responses to H1N1/09 vaccine in HIV-infected patients  Suresh Pallikkuth, PhD, Sudheesh Pilakka.

Published byChrystal Erika Todd Modified over 4 years ago

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Presentation on theme: "Innate immune defects correlate with failure of antibody responses to H1N1/09 vaccine in HIV-infected patients  Suresh Pallikkuth, PhD, Sudheesh Pilakka."— Presentation transcript:

1 Innate immune defects correlate with failure of antibody responses to H1N1/09 vaccine in HIV-infected patients  Suresh Pallikkuth, PhD, Sudheesh Pilakka Kanthikeel, PhD, Sandra Y. Silva, MD, Margaret Fischl, MD, Rajendra Pahwa, MD, Savita Pahwa, MD  Journal of Allergy and Clinical Immunology  Volume 128, Issue 6, Pages (December 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 H1N1/09 Rs show expansion of memory B cells: frequencies of memory B cells (CD20+ CD27+ CD10−) in total (CD20+) B cells (A), KI67+ memory B cells (B), and IgG-producing ASCs (C) following ex vivo stimulation with H1N1 antigen. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Serum BAFF and APRIL levels are increased in H1N1/09 R patients: Serum levels of BAFF and APRIL were measured by ELISA. A, Serum levels of BAFF. B, Serum levels of APRIL. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Differential expression of BAFF-R and TACI in R and NR patients: representative histograms showing frequency of BAFF-R (A) and TACI (D) in total B cells at T0 (gray) and T2 (black) compared with isotype controls (filled). Expression of BAFF-R+ in total B cells (B) and memory B cells (C). TACI expression in total B cells (E) and memory B cells (F). Correlation between the H1N1 Ab titer with BAFF-R+ B cells (G) and TACI+ B cells (H). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 H1N1 antigen-stimulated IL-2, IFNγ, and IgG responses in HCs and HIV-infected patients pre- and post-H1N1 vaccination: frequencies of H1N1-stimulated IFN-γ (A) and IL-2–producing SFUs (B) in PBMCs at T0 and T2. C, Correlation between the H1N1 Ab titer and IL-2 SFUs in PBMC ELISpot assay. D, Mean H1N1-stimulated IgG ASCs with and without exogenous IL-2 at T0 and T2. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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