1. IL-1R deficiency does not protect syngeneic grafts from destruction.
IL-1R deficiency does not protect syngeneic grafts from destruction. Fetal pancreas grafts were harvested from NODscid mice after adoptive transfer of splenocytes from diabetic NOD mice. Recipient mice were nondiabetic treated with placebo (A and B) or nondiabetic treated with IL-1Ra (D and E). Serial sections were stained with insulin and glucagon to visualize islet structures. Representative wild-type and IL-1R-deficient grafts of the two groups stained with insulin are shown. C and F: Pancreas sections from each group stained with hemotoxylin and eosin are also shown to demonstrate that insulitis caused by the adoptive transfer was unaffected by the treatment.
Helen E. Thomas et al. Diabetes 2004;53:
©2004 by American Diabetes Association