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Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts  Debbie Montjean, M.Sc., Moncef Benkhalifa,

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Presentation on theme: "Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts  Debbie Montjean, M.Sc., Moncef Benkhalifa,"— Presentation transcript:

1 Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts  Debbie Montjean, M.Sc., Moncef Benkhalifa, Ph.D., Lionel Dessolle, M.D., Paul Cohen-Bacrie, D.Pharm., Stéphanie Belloc, D.Pharm., Jean-Pierre Siffroi, M.D., Ph.D., Célia Ravel, M.D., Ph.D., Anu Bashamboo, Ph.D., Kenneth McElreavey, Ph.D.  Fertility and Sterility  Volume 95, Issue 2, Pages (February 2011) DOI: /j.fertnstert Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Box plot showing sperm parameters according to MTHFR 665 genotype. Similar results were found for other MTHFR and MTRR genotypes. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Effect of MTHFR 665 polymorphism on plasma Hcy level and impact of Hcy level variation on sperm counts. (A) Box plot showing Hcy levels according to MTHFR 665 genotype. (B) Linear regression of sperm counts according to Hcy levels. Gray lines represent the 95% CIs of the sperm counts distribution and predictions. Hcy levels are expressed in μmol/L. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions


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