1. The Podocyte Under Stress: AKT2 to the Rescue
Sundararaman Swaminathan, MD, Mitchell H. Rosner, MD 
American Journal of Kidney Diseases 
Volume 63, Issue 4, Pages (April 2014)
DOI: /j.ajkd
Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

2. Figure 1
The AKT2 pathway is induced by mTORC2 under conditions of podocyte stress such as that seen in clinical conditions associated with nephron loss. When activated, AKT2 acts to protect the podocyte through inhibition of apoptosis, as well as through downregulation of RAC1, which otherwise would lead to podocyte foot-process effacement.
American Journal of Kidney Diseases  , DOI: ( /j.ajkd )
Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions