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Effects of propofol on the expression of matric metalloproteinases in rat cardiac fibroblasts after hypoxia and reoxygenation  J.H. Jun, J.E. Cho, Y.H.

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Presentation on theme: "Effects of propofol on the expression of matric metalloproteinases in rat cardiac fibroblasts after hypoxia and reoxygenation  J.H. Jun, J.E. Cho, Y.H."— Presentation transcript:

1 Effects of propofol on the expression of matric metalloproteinases in rat cardiac fibroblasts after hypoxia and reoxygenation  J.H. Jun, J.E. Cho, Y.H. Shim, J.K. Shim, Y.L. Kwak  British Journal of Anaesthesia  Volume 106, Issue 5, Pages (May 2011) DOI: /bja/aer006 Copyright © 2011 The Author(s) Terms and Conditions

2 Fig 1 Propofol-induced changes in AKT and ERK signalling for the indicated times (a, upper panel) and at the indicated concentration (b, upper panel), and quantified signal (a and b, lower panel). Figure shows raw data points. British Journal of Anaesthesia  , DOI: ( /bja/aer006) Copyright © 2011 The Author(s) Terms and Conditions

3 Fig 2 (a–h) Propofol induced MMPs and TIMP-2 mRNA expression under normoxic conditions. (i) Effect of propofol on MMP-2 and -9 expression and quantified signal by scanning densitometry (lower panel). Figure shows raw data points. C, control; MMPs, matrix metalloproteinases; P, propofol; TIMP, tissue inhibitors of metalloproteinase. British Journal of Anaesthesia  , DOI: ( /bja/aer006) Copyright © 2011 The Author(s) Terms and Conditions

4 Fig 3 (a–d) Effect of inhibiting ERK and AKT signalling pathway on propofol-induced MMPs and TIMPs gene expression. (e and f) The levels of pro- and active MMP-2 in conditioned media and quantified signal (lower panel). (g) Effect of U0126 (U), or LY (L) on ERK and AKT activation, and (h) quantified signal. Figure shows raw data points. C, control; MMPs, matrix metalloproteinases; P, propofol; TIMP, tissue inhibitors of metalloproteinase. British Journal of Anaesthesia  , DOI: ( /bja/aer006) Copyright © 2011 The Author(s) Terms and Conditions

5 Fig 4 Propofol induced changes in MMP-1, -2, -9, and -13 and TIMP-1, -2, and -3 for the indicated time. Figure shows raw data points. H, hypoxia; MMPs, matrix metalloproteinases; N, normoxia; P, pre-treatment; TIMP, tissue inhibitors of metalloproteinase. British Journal of Anaesthesia  , DOI: ( /bja/aer006) Copyright © 2011 The Author(s) Terms and Conditions

6 Fig 5 (a and b) Effect of propofol on cell migration and invasion. Figure shows raw data points. (c) Effect of propofol on cell proliferation assay. Data are means (se). *Significant difference from the control (P<0.05). C, control; LY, LY294002; P, propofol; U, U0126. British Journal of Anaesthesia  , DOI: ( /bja/aer006) Copyright © 2011 The Author(s) Terms and Conditions

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