1. Constantijn Franssen et al. JCHF 2016;4:312-324
Oxidative Stress in HFpEF Patients and ZSF1-HFpEF Rats (A) HFpEF patients had higher myocardial concentrations of H2O2 than AS and HFrEF (#p < 0.05 vs. AS; *p < 0.05 vs. HFrEF). (B) Myocardial H2O2 concentrations in ZSF1-HFpEF were higher than in ZSF1-Ctrl rats (*p < 0.05). (C) Expression of NOX2 was comparable in cardiomyocytes but tended to be higher in macrophages of HFpEF patients. (D) Expression of NOX2 was comparable in cardiomyocytes of ZSF1-Ctrl and ZSF1-HFpEF rats. More NOX2-expressing macrophages were observed in ZSF1-HFpEF rats (*p < 0.05 vs. controls). NOX2 = NADPH oxidase 2; other abbreviations as in Figure 1.
Constantijn Franssen et al. JCHF 2016;4:
American College of Cardiology Foundation