1. C/EBPα induces HSD1 expression and is a substrate of USP2–45.
C/EBPα induces HSD1 expression and is a substrate of USP2–45. A and B: Induction of HSD1 mRNA (A) and protein (B) expression by C/EBPα in primary hepatocytes. *P < 0.01, C/EBPα vs. GFP. C: Deubiquitination of C/EBPα by USP2–45 in transiently transfected 293 cells. D: Model depicting the role of USP2–45 in mediating circadian and nutritional regulation of hepatic gluconeogenesis and glucose secretion.
Matthew M. Molusky et al. Diabetes 2012;61:
©2012 by American Diabetes Association