1. Selected host cell processes targeted by Dot/Icm effectors demonstrating the complexity of LCV biogenesis and maintenance as well as the broad range of effectors and pathways involved.
Selected host cell processes targeted by Dot/Icm effectors demonstrating the complexity of LCV biogenesis and maintenance as well as the broad range of effectors and pathways involved. L. pneumophila effectors attack numerous cellular structures and host proteins; major targets include (clockwise from top left) host GTPases regulating vesicle trafficking, membrane phosphoinositides, host protein synthesis and stress response machinery, cell apoptosis, and host ubiquitination pathways. See the text for details. Larger circles represent ER-derived vesicles.
Hayley J. Newton et al. Clin. Microbiol. Rev. 2010; doi: /CMR