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Fighting Malaria: Mosquitoes Know How

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1 Fighting Malaria: Mosquitoes Know How
Bruce Beutler  Immunity  Volume 25, Issue 4, Pages (October 2006) DOI: /j.immuni Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 The Ookinete and Its Vulnerability to TEP1
Arising from the fusion of male and female gametocytes, the zygote yields ookinetes that penetrate the wall of the midgut asynchronously, over a period of 16 to 20 hr. This process is resisted by “basal immunity,” under the control of transcription factors Rel1 and Rel2, and leads to a state of “induced immunity.” Induced immunity permits replenishment of parasite-killing factors such as TEP1. Immunity  , DOI: ( /j.immuni ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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