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Balancing the Risks and Benefits of Multidrug Regimens in the Clinical Management of Nontuberculous Mycobacterial Lung Disease.

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Presentation on theme: "Balancing the Risks and Benefits of Multidrug Regimens in the Clinical Management of Nontuberculous Mycobacterial Lung Disease."— Presentation transcript:

1 Balancing the Risks and Benefits of Multidrug Regimens in the Clinical Management of Nontuberculous Mycobacterial Lung Disease

2 Program Overview

3 NTM Lung Disease Introduction

4 Radiographic Manifestations

5 Predisposing Factors

6 Managing NTM Lung Disease Can Be Challenging

7 Determining Who To Treat

8 Guideline-Based Recommendations for Treating NTM Lung Disease

9 Standard Treatment for MAC, Macrolide-Susceptible Disease

10 Standard Treatment for MAC, Macrolide-Susceptible Disease (cont)

11 When Is Treatment NOT Indicated?

12 Treatment-Related AEs Standard Care

13 Monitoring Response

14 Unresolved Questions

15 Unresolved Questions (cont)

16 Unresolved Questions (cont)

17 Benefits of Inhaled Therapies

18 ALIS Overview

19 Phase 2 Trial ALIS

20 Treatment-Related AEs ALIS vs Placebo

21 Findings ALIS Phase 2 Trial

22 Phase 3 Trial CONVERT

23 Findings CONVERT Trial

24 Treatment-Related AEs CONVERT Trial

25 Who Best Benefits From ALIS?

26 Bedaquiline Overview

27 Case Series Bedaquiline

28 Treatment-Related AEs Bedaquiline

29 Oxazolidinones Tedizolid, Linezolid Overview

30 Clofazimine Overview

31 Treatment-Related AEs Clofazimine

32 Nitric Oxide Overview

33 Concluding Remarks

34 Abbreviations


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