1. Julie Bourbeillon 26/07/2005 Multimedia Data Management To Assist Tissue MicroArray Design Laboratoire TIMC-IMAG – Grenoble, France Equipes SIC et RFMQ Julie Bourbeillon, Catherine Garbay et Françoise Giroud AIME 2005 1

2. Julie Bourbeillon 26/07/2005 TMA Technology 2 Study to conduct Patients

3. Julie Bourbeillon 26/07/2005 TMA Technology Histological Slide Biopsy Study to conduct Patients 2

4. Julie Bourbeillon 26/07/2005 TMA Technology Histological Slide Biopsy 2 Study to conduct Patients TMA Block Building process

5. Julie Bourbeillon 26/07/2005 TMA Technology Histological Slide Biopsy 2 Study to conduct Biological Marker TMA Sildes Patients TMA Block Building process

6. Julie Bourbeillon 26/07/2005 TMA Technology Histological Slide Biopsy 2 Study to conduct Image Acquisition Biological Marker TMA Sildes Patients TMA Block Building process

7. Julie Bourbeillon 26/07/2005 TMA Technology Histological Slide Biopsy 2 Study to conduct Data Mining Image Acquisition Biological Marker TMA Sildes Patients TMA Block Building process Anatomopathological Analysis Quantitative Microscopy

8. Julie Bourbeillon 26/07/2005 TMA Technology Histological Slide Biopsy 2 Study to conduct Virtual TMA Silde Data Mining Image Acquisition Biological Marker TMA Sildes Patients TMA Block Building process Anatomopathological Analysis Quantitative Microscopy

9. Julie Bourbeillon 26/07/2005 TMA Technology Histological Slide Biopsy 2 Study to conduct Virtual TMA Silde Data Mining Image Acquisition Biological Marker TMA Sildes Patients TMA Block Building process Anatomopathological Analysis Quantitative Microscopy Assist With Real TMA Blocks Construction Building plan for TMA Blocks

10. Julie Bourbeillon 26/07/2005 TMA Technology Histological Slide Biopsy 2 Study to conduct Virtual TMA Silde Data Mining Image Acquisition Biological Marker TMA Sildes Patients TMA Block Building process Anatomopathological Analysis Quantitative Microscopy Assist With TMA Data Mining Building TMA Virtual Slides

11. Julie Bourbeillon 26/07/2005 TMA Technology Histological Slide Biopsy 2 Study to conduct Virtual TMA Silde Data Mining Image Acquisition Biological Marker TMA Sildes Patients TMA Block Building process Anatomopathological Analysis Quantitative Microscopy How to assist ? Manipulating heterogenous data - Images Building an organised prsentation of those items Multimedia document generation

12. Julie Bourbeillon 26/07/2005 TMA Technology Histological Slide Biopsy 2 Study to conduct Virtual TMA Silde Data Mining Image Acquisition Biological Marker TMA Sildes Patients TMA Block Building process Anatomopathological Analysis Quantitative Microscopy Using : Constraints expressed in the query How to assist ? Manipulating heterogenous data - Images Building an organised prsentation of those items Multimedia document generation

13. Julie Bourbeillon 26/07/2005 TMA Technology Histological Slide Biopsy 2 Study to conduct Virtual TMA Silde Data Mining Image Acquisition Biological Marker TMA Sildes Patients TMA Block Building process Anatomopathological Analysis Quantitative Microscopy Using : Constraints expressed in the query Using : Experimental and technological Constraints How to assist ? Manipulating heterogenous data - Images Building an organised prsentation of those items Multimedia document generation

14. Julie Bourbeillon 26/07/2005 Multimedia Document Multimedia Document to build Slection / Organisation Criteria 1. User Query 2. TMA Grid 3. Similar Studies Spot Image Associated Patient Medical Data Biological Material Image Annotation / Analysis Description de structures Quantification de marquage Biological Reference Cell Line / Normal Tissue 4. Bibliography 5. Molecule / Gene Information Publication / Knowledge Acquisition Articles Database entries 3

15. Julie Bourbeillon 26/07/2005 Adaptation engine 5 Patient Oriented Virtual Documents Factual Comp. Logical Comp. Factual Level Virtual Document Patient Collection Document Logical Model Task Oriented Virtual Document Lay-out Comp. Document Lay-out Model User Final TMA Document Logical LevelLay-out Level SelectionOrganisation Presentation Query Layer Goal Layer Domain Layer Composition Specialisation User Query Adaptation Plan Adaptation Model Criteria Collection Query Model

16. Julie Bourbeillon 26/07/2005 Adaptation engine 5 Patient Oriented Virtual Documents Factual Comp. Logical Comp. Factual Level Virtual Document Patient Collection Document Logical Model Task Oriented Virtual Document Lay-out Comp. Document Lay-out Model User Final TMA Document Logical LevelLay-out Level SelectionOrganisation Presentation Query Layer Goal Layer Domain Layer Composition Specialisation User Query Adaptation Plan Adaptation Model Criteria Collection Query Model Specialisation axis: Progressive refinement towards a particular case

17. Julie Bourbeillon 26/07/2005 Adaptation engine 5 Patient Oriented Virtual Documents Factual Comp. Logical Comp. Factual Level Virtual Document Patient Collection Document Logical Model Task Oriented Virtual Document Lay-out Comp. Document Lay-out Model User Final TMA Document Logical LevelLay-out Level SelectionOrganisation Presentation Query Layer Goal Layer Domain Layer Composition Specialisation User Query Adaptation Plan Adaptation Model Criteria Collection Query Model Composition axis: Process split-up to ease the adaptation

18. Julie Bourbeillon 26/07/2005 Adaptation engine architecture defined For now applied to TMA technology Better detailled on the Poster Other applications in other domains Analysis of data with temporal or spatial dimensions Navigation in large volumes of structured data Perspectives Better characterise the knowledge required for the adaptation process Define a quality assessment system for the generated documents Validate the model with a prototype (in particular genericity) Conclusion 5

19. Julie Bourbeillon 26/07/2005 Multimedia Data Management To Assist Tissue MicroArray Design Laboratoire TIMC-IMAG – Grenoble, France Equipes SIC et RFMQ Julie Bourbeillon, Catherine Garbay et Françoise Giroud AIME 2005 6