1. Fig. 4 Kinetics of dissolution and histological studies of bioresorbable optical sensors and fibers.
Kinetics of dissolution and histological studies of bioresorbable optical sensors and fibers. (A) Optical micrographs at various stages of accelerated dissolution of a bioresorbable FPI sensor due to immersion in PBS (pH 7.4) at 95°C. (B) Schematic illustration of the setup used for the dissolution experiment in (A). (C) Pressure calibration curves obtained from a bioresorbable FPI pressure sensor (t-SiO2 thickness, 1 μm; air chamber thickness, 100 μm), integrated with a commercial optical fiber, soaked in PBS at 37°C for 8 days. The minimal changes in pressure sensitivity provide evidence for the effectiveness of t-SiO2 as a biofluid barrier. (D) Loss of transmission efficiency of the PLGA fiber over time due to immersion in PBS at 37°C. Circles and error bars indicate means ± SEM for four measurements. (E) Representative histological results of the brain, heart, kidney, liver, lung, and spleen organs explanted from a control mouse and a mouse with a bioresorbable FPI sensor implanted in the brain for 5 weeks. The results indicate an absence of abnormalities such as necrosis or inflammation.
Jiho Shin et al. Sci Adv 2019;5:eaaw1899
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