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HT synthesis of boronic acids using the building block approach

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Presentation on theme: "HT synthesis of boronic acids using the building block approach"— Presentation transcript:

1 Fig. 3 HT synthesis of boronic acids using the building block approach.
HT synthesis of boronic acids using the building block approach. (A) Exemplary analytical 384-well plate of the U-4CR scaffold 12 (green, major product formation; yellow, product present; blue, product not present). (B) Statistical analysis of the quality of reactions of the different scaffolds. (C) Structures of some unusual reaction products from different IMCRs. Constantinos G. Neochoritis et al. Sci Adv 2019;5:eaaw4607 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

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Fig. 1 Importance of boronic acids, commonly used synthetic methods for the ─B(OH)2 introduction, and our proposed building block–centered approach. Importance.

Fig. 1 Importance of boronic acids, commonly used synthetic methods for the ─B(OH)2 introduction, and our proposed building block–centered approach. Importance.
HT Suzuki reaction of boronic acids using the building block approach

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