1. The Blurred Line Between RRMS and SPMS: Can Novel Tools Bring SPMS Diagnosis Into Focus?

2. This program will include a discussion of data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.

3. MS Subtypes and Clinical Course

4. Detecting Disease Activity

5. Characteristic Signs and Symptoms of SPMS

6. Detecting Progression to SPMS

7. Challenges in Detecting and Measuring Progression

8. Treatments and Indications for SPMS

9. Recent RCTs in SPMS

10. Defining Endpoints When Measuring Progression

11. Biomarkers in Use or Development in MS: Identifying or Predicting Progression

12. Focal Cord and Brain Lesions in RRMS and SPMS

13. Neurofilament Light Chain as a Marker of Progression

14. A Tool to Define SPMS: Lorscheider Tool

15. Clinical History for Detecting Progression

16. Web-Based MS Progression Discussion Tool

17. MS Progression Discussion Tool: Clinical Information to Input, Parts 1 and 2

18. MS Progression Discussion Tool: Clinical Information to Input, Parts 1, 2, and 3

19. Development Process for the Tool: Ability to Differentiate Between RRMS and SPMS

20. Using the Tool: Next Steps

21. Case 1: 45-Year-Old Policeman With Clear Signs of SPMS

22. Case 1: Quality of Life and Emotional State

23. Case 2: A 35-Year-Old Teacher

24. Case 2: Quality of Life and Emotional State

25. MS Progression Discussion Tool: Page 1, Patient and Disease Characteristics

26. Page 2, Signs and Symptoms

27. Page 3, Impact of Symptoms

28. MS Progression Discussion Tool: Page 4, Results

29. Practical Application of the Tool: Future Perspectives

30. Additional Considerations: Patient Feedback

31. Comparison With Other Tools in SPMS

32. Abbreviations