1. Ophthalmology Glaucoma
Once-Daily Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure in the Randomized Phase 3 MERCURY-2 Study 
Thomas R. Walters, MD, Iqbal Ike K. Ahmed, MD, Richard A. Lewis, MD, Dale W. Usner, PhD, Jae Lopez, BA, Casey C. Kopczynski, PhD, Theresa Heah, MD 
Ophthalmology Glaucoma 
DOI: /j.ogla
Copyright © 2019 American Academy of Ophthalmology Terms and Conditions

2. Figure 1 Patient disposition. FDC = fixed-dose combination.
Ophthalmology Glaucoma DOI: ( /j.ogla )
Copyright © 2019 American Academy of Ophthalmology Terms and Conditions

3. Figure 2
Mean IOP (intent-to-treat population). Markov Chain Monte Carlo used to impute missing data. ∗∗∗P < versus netarsudil and latanoprost. Two-sided P values. CI = confidence interval; FDC = fixed-dose combination; IOP = intraocular pressure; SEM = standard error of the mean.
Ophthalmology Glaucoma DOI: ( /j.ogla )
Copyright © 2019 American Academy of Ophthalmology Terms and Conditions

4. Figure 3
Percentages of patients at month 3 reaching prespecified targets for (A) percent reduction from baseline in mean diurnal IOP and (B) mean diurnal IOP. Observed data only. ∗∗∗P < versus netarsudil and latanoprost. ###P < versus netarsudil and P < 0.05 versus latanoprost. Fisher exact test. FDC = fixed-dose combination; IOP = intraocular pressure.
Ophthalmology Glaucoma DOI: ( /j.ogla )
Copyright © 2019 American Academy of Ophthalmology Terms and Conditions

5. Figure 4
Mean conjunctival hyperemia score via biomicroscopy (8:00 am). Biomicroscopic grading of conjunctival hyperemia was performed on a standardized, 4-point scale (0 = none [normal; appears white with a small number of conjunctival blood vessels easily observed]; 1 = mild [prominent pinkish-red color of both the bulbar and palpebral conjunctiva]; 2 = moderate [bright, scarlet red color of the bulbar and palpebral conjunctiva]; 3 = severe [“beefy red” with petechiae; dark red bulbar and palpebral conjunctiva with evidence of subconjunctival hemorrhage]). FDC = fixed-dose combination.
Ophthalmology Glaucoma DOI: ( /j.ogla )
Copyright © 2019 American Academy of Ophthalmology Terms and Conditions