Presentation is loading. Please wait.

Presentation is loading. Please wait.

Fig. 6 Covalent inhibition of tuberculosis target MptpB.

Published byEva Weber Modified over 5 years ago

Similar presentations

Presentation on theme: "Fig. 6 Covalent inhibition of tuberculosis target MptpB."— Presentation transcript:

1 Fig. 6 Covalent inhibition of tuberculosis target MptpB.
Covalent inhibition of tuberculosis target MptpB. (A) Screening of the boronic acid library by a colorimetric enzyme assay. (B) Median inhibitory concentration (IC50) of compound 18a. (C and D) Modeling of compound 18a into MptpB [Protein Data Bank (PDB) ID: 2OZ5], where it forms a covalent adduct with active-site cysteine. Van der Waals interactions, hydrogen bonding, and cation-π interactions are indicated by yellow, red, and blue dotted lines, respectively. Constantinos G. Neochoritis et al. Sci Adv 2019;5:eaaw4607 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

Download ppt "Fig. 6 Covalent inhibition of tuberculosis target MptpB."

Similar presentations

Fig. 4 3D reconfiguration of liquid metals for electronics.

Fig. 4 3D reconfiguration of liquid metals for electronics.
Fig. 4 Ballistic simulation of BP FETs.

Fig. 4 Ballistic simulation of BP FETs.
Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,
Fig. 4 INS spectra of different human bones from the Roman period [humerus, ulna, femur, and fibula from the same skeleton, Guidonia-Montecelio, Italy.

Fig. 4 INS spectra of different human bones from the Roman period [humerus, ulna, femur, and fibula from the same skeleton, Guidonia-Montecelio, Italy.
Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)

Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)
Fig. 3 Projected gains in MCP.

Fig. 3 Projected gains in MCP.
Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.
Fig. 1 Evolution of magnetic field lines around a foreshock bubble in the GSE-XY plane (z = 0): Results of a hybrid simulation. Evolution of magnetic field.

Fig. 1 Evolution of magnetic field lines around a foreshock bubble in the GSE-XY plane (z = 0): Results of a hybrid simulation. Evolution of magnetic field.
Fig. 1 Map of water stress and shale plays.

Fig. 1 Map of water stress and shale plays.
Fig. 3 Electron PSD in various regions.

Fig. 3 Electron PSD in various regions.
Fig. 4 Complete separation of water and solute after stable and efficient solar evaporation. Complete separation of water and solute after stable and efficient.

Fig. 4 Complete separation of water and solute after stable and efficient solar evaporation. Complete separation of water and solute after stable and efficient.
Fig. 2 Some examples of weekly forecasts (the number of the forecasts are reported on Table 1). Some examples of weekly forecasts (the number of the forecasts.

Fig. 2 Some examples of weekly forecasts (the number of the forecasts are reported on Table 1). Some examples of weekly forecasts (the number of the forecasts.
Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.
Fig. 1 Importance of boronic acids, commonly used synthetic methods for the ─B(OH)2 introduction, and our proposed building block–centered approach. Importance.

Fig. 1 Importance of boronic acids, commonly used synthetic methods for the ─B(OH)2 introduction, and our proposed building block–centered approach. Importance.
HT Suzuki reaction of boronic acids using the building block approach

HT Suzuki reaction of boronic acids using the building block approach
HT synthesis of boronic acids using the building block approach

HT synthesis of boronic acids using the building block approach
Fig. 6 Comparison of properties of water models.

Fig. 6 Comparison of properties of water models.
Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.

Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.
Fig. 2 Influence of the Roadmap Epigenomics Program on the field of epigenomics research. Influence of the Roadmap Epigenomics Program on the field of.

Fig. 2 Influence of the Roadmap Epigenomics Program on the field of epigenomics research. Influence of the Roadmap Epigenomics Program on the field of.
Fig. 2 Reference-fixing experiment, results.

Fig. 2 Reference-fixing experiment, results.

Similar presentations

Ads by Google