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Obesity and androgens: facts and perspectives

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1 Obesity and androgens: facts and perspectives
Renato Pasquali, M.D.  Fertility and Sterility  Volume 85, Issue 5, Pages (May 2006) DOI: /j.fertnstert Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 Schematic view of the interaction between androgens and obesity and its different phenotypes. Pasquali. Obesity and androgens. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

3 FIGURE 2 Luteinizing hormone (LH) pituitary secretion is related to body mass index in men. Mean diurnal levels = integrated (diurnal) levels measured as the mean of the values obtained over 12 h; Σ pulse amplitude = sum of all diurnal pulse amplitudes of LH. From Vermeulen et al. (19), with permission of the editor. Pasquali. Obesity and androgens. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

4 FIGURE 3 The relationship between free androgen index (FAI) and the hypothalamic-pituitary-adrenal axis (evaluated by the cortisol response to combined corticotropin-releasing hormone and arginine vasopressin stimulation) in obese men (A) and obese women (B). (from reference 63, with permission of the editor.) Pasquali. Obesity and androgens. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

5 FIGURE 4 Relationship between leptin and basal (right) and hCG-stimulated (left) testosterone (expressed as the ratio between 17-hydroxyprogesterone (17-OHP) and testosterone (T) (A, left) and the ratio between E2 and T (B, left) in overweight (BMI<30) and obese (BMI 30–40 and BMI >40) males. From Isidori et al. (90), with permission of the editor. Pasquali. Obesity and androgens. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions


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