1. Shp2 is required for lens and lacrimal gland development.
Shp2 is required for lens and lacrimal gland development. (A-D) The Le-Cre;Shp2flox/flox mutant lens exhibited normal primary lens fiber cell elongation at E12.5 but reduced lens size at E14.5. (E-H) The anterior lens epithelial cells shifted posteriorly in the E15.5 Le-Cre;Shp2flox/flox mutant lens (arrowheads), and no lacrimal gland was detected (arrows). (I,J) At P0, the Le-Cre;Shp2flox/flox mutant lens was completely surrounded by epithelial cells (arrowheads), indicating a failure of lens epithelial cell differentiation. Scale bars: 100 μm. LE, lens epithelium; LF, lens fiber; LG, lacrimal gland.
Yi Pan et al. Development 2010;137:
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