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Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Thymidylate Synthase and Risk of Pancreatic Cancer Li Wang, Xiaoping Miao, Wen Tan, Xinghua Lu, Ping Zhao, Xiaohang Zhao, Yi Shan, Hui Li, Dongxin Lin Clinical Gastroenterology and Hepatology Volume 3, Issue 8, Pages (August 2005) DOI: /S (05) Copyright © 2005 American Gastroenterological Association Terms and Conditions
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Figure 1 Overview of the human folate metabolism underlying the importance of folate methyl groups for both DNA methylation and DNA synthesis. DHF, dihydrofolate; THF, tetrahydrofolate; MS, methionine synthase; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; dUMP, deoxyuridine monophosphate; dTMP, thymidine monophosphate. Clinical Gastroenterology and Hepatology 2005 3, DOI: ( /S (05) ) Copyright © 2005 American Gastroenterological Association Terms and Conditions
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