1. Changes in histone acetylation caused by progressive mtDNA depletion occur in specific loci and are robust already at day 3.
Changes in histone acetylation caused by progressive mtDNA depletion occur in specific loci and are robust already at day 3. (A) Average genome-wide enrichment level of H3K9ac peaks DNA centered around the TSS of genes. N = 2 per time point. Blue line shows data for H3K9ac and black lines for input DNA. (B) Time-dependent patterns of average significantly different enriched H3K9ac peaks relative to day 9 in the DN-POLG cells following hierarchical clustering; error bars represent standard error of the mean.
Oswaldo A Lozoya et al. LSA 2019;2:e
© 2019 Lozoya et al.