1. Volume 58, Issue 3, Pages 1135-1147 (September 2000)
Renovascular hypertension does not influence repair of glomerular lesions induced by anti-thymocyte glomerulonephritis 
Ulrich O. Wenzel, Gunter Wolf, Friedrich Thaiss, Udo Helmchen, Rolf A.K. Stahl 
Kidney International 
Volume 58, Issue 3, Pages (September 2000)
DOI: /j x
Copyright © 2000 International Society of Nephrology Terms and Conditions

2. Figure 1
Animal survival in the four experimental groups six weeks after induction of the nephritis is shown. Abbreviations are: CON, normotensive controls; 2K1C, two-kidney, one-clip hypertensive animals; ATS, nephritis. *P < 0.05 and **P < vs. normotensive controls.
Kidney International  , DOI: ( /j x)
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3. Figure 2
Systolic blood pressure measured in conscious rats six weeks after the induction of the nephritis is shown. Abbreviations are in the legend to Figure 1. *P < vs. normotensive controls.
Kidney International  , DOI: ( /j x)
Copyright © 2000 International Society of Nephrology Terms and Conditions

4. Figure 3
Proteinuria of the various groups is shown. Abbreviations are in the legend to Figure 1. *P < vs. normotensive controls.
Kidney International  , DOI: ( /j x)
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5. Figure 4
Glomeruli of normotensive nephritic rats revealed by light microscopy no more proliferative disease (B). They were indistinguishable from normotensive controls (A; PAS ×400). For comparison, (C) shows a glomerulus five days after injection of the same batch of antiserum, which was used in the present study, demonstrating glomerular extracellular matrix expansion. The glomeruli of the clipped kidney with (E) or without nephritis (D) generally had a normal appearance. Light microscopy of glomeruli in the nonclipped kidney from rat that received ATS had structural changes that are characterized by an increase in mesangial matrix and sclerosis (G). However, no significant difference could be detected in comparison to the nonclipped kidney of hypertensive rats without nephritis (F).
Kidney International  , DOI: ( /j x)
Copyright © 2000 International Society of Nephrology Terms and Conditions

6. Figure 5
Glomerular sclerosis evaluated by scoring is shown. Glomerular sclerosis was significantly increased in the nonclipped kidney, but no significant difference could be detected for the nonclipped kidney between nephritic and non-nephritic rats. P < vs. normotensive controls.
Kidney International  , DOI: ( /j x)
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7. Figure 6
Tubulointerstitial damage evaluated by scoring is shown. Tubulointerstitial injury was significantly increased in the nonclipped kidneys, but no significant difference could be detected for the nonclipped kidney between nephritic and non-nephritic rats. *P < 0.05; **P < vs. normotensive controls.
Kidney International  , DOI: ( /j x)
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8. Figure 7
Immunohistological staining of renal tissue with a fibronectin antibody revealed an increase of glomerular fibronectin deposition in the nonclipped kidney of non-nephritic (B) and nephritic rats (C) compared with control rats (A).
Kidney International  , DOI: ( /j x)
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9. Figure 7
Immunohistological staining of renal tissue with a fibronectin antibody revealed an increase of glomerular fibronectin deposition in the nonclipped kidney of non-nephritic (B) and nephritic rats (C) compared with control rats (A).
Kidney International  , DOI: ( /j x)
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10. Figure 8
Western blotting for α smooth muscle actin from glomerular proteins. The 30 and 46 kD molecular marker is shown on the left. α Smooth muscle expression was enhanced in glomeruli from the nonclipped kidneys in non-nephritic and nephritic rats. This Western blot was repeated twice with similar results.
Kidney International  , DOI: ( /j x)
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11. Figure 9
By Western blotting, p27Kip1 was detectable in isolated glomeruli. Expression of p27Kip1 was increased in the nonclipped kidney, but no difference could be detected between nephritic and non-nephritic rats. This Western blot was repeated twice with similar results.
Kidney International  , DOI: ( /j x)
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12. Figure 10
Expression of glomerular TGF-β protein levels. The 30 kD molecular marker is shown on the left. A single band of around 25 kD is visible reflecting the TGF-β dimer. Hypertensive rats showed increased levels of TGF-β in the nonclipped kidney compared with the clipped kidney and controls. The expression of TGF-β in the clipped and nonclipped kidney of hypertensive nephritic rats was similar to hypertensive rats without nephritis. This Western blot was repeated twice with similar results.
Kidney International  , DOI: ( /j x)
Copyright © 2000 International Society of Nephrology Terms and Conditions