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Molecular profiling of experimental endometriosis identified gene expression patterns in common with human disease  Idhaliz Flores, Ph.D., Elizabeth Rivera,

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Presentation on theme: "Molecular profiling of experimental endometriosis identified gene expression patterns in common with human disease  Idhaliz Flores, Ph.D., Elizabeth Rivera,"— Presentation transcript:

1 Molecular profiling of experimental endometriosis identified gene expression patterns in common with human disease  Idhaliz Flores, Ph.D., Elizabeth Rivera, M.Ed., Lynnette A. Ruiz, B.S., Olga I. Santiago, B.S., Michael W. Vernon, Ph.D., Caroline B. Appleyard, Ph.D.  Fertility and Sterility  Volume 87, Issue 5, Pages (May 2007) DOI: /j.fertnstert Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 Scatter plots of gene expression levels in experimental (n = 6) and control (n = 5) rats analyzed by RT-PCR. Unpaired t tests were conducted to determine significant differences in the mean level of gene expression between the groups. Significance was set at P<.05; *P<.05, **P<.01. Flores. Molecular profiling of rat endometriosis. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

3 FIGURE 2 Comparison of fold-expression of candidate genes in ectopic vs. eutopic endometrium analyzed by either microarrays or real-time QRT-PCR. Flores. Molecular profiling of rat endometriosis. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

4 FIGURE 3 A model of disease for endometriosis based on data from both animal and human studies. Flores. Molecular profiling of rat endometriosis. Fertil Steril 2007. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions


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