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Fig. 1 Intrarenal lymphangiogenesis in patients with CKD accompanied by intrarenal inflammatory cells and renal fibrosis. Intrarenal lymphangiogenesis.

Published byBrandon Foster Modified over 5 years ago

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Presentation on theme: "Fig. 1 Intrarenal lymphangiogenesis in patients with CKD accompanied by intrarenal inflammatory cells and renal fibrosis. Intrarenal lymphangiogenesis."— Presentation transcript:

1 Fig. 1 Intrarenal lymphangiogenesis in patients with CKD accompanied by intrarenal inflammatory cells and renal fibrosis. Intrarenal lymphangiogenesis in patients with CKD accompanied by intrarenal inflammatory cells and renal fibrosis. (A) Intrarenal LVs in kidneys of various pathological types and healthy control kidneys immunolabeled with D2-40. MCD, minimal change disease; MN, membranous nephropathy; IgAN, IgA nephropathy; LN, lupus nephritis; TIN, tubulointerstitial nephritis; ON, obstructive nephropathy. (B) D2-40 (red) and PCNA (green) dual immunolabeling to identify proliferating intrarenal lymphatic endothelium in control (n = 8) and CKD patients (n = 20). (C) Representative images (40×) showing intrarenal pro-lymphangiogenesis cytokines in control (n = 8) and CKD patient (n = 20) samples. Left: Immunohistochemical staining. Right: Area positive for pro-lymphangiogenesis cytokines counted in high-power field (HPF). (D) Dual immunostaining of CKD renal biopsy specimens: D2-40 (red), CCL21 (green), and CCR7 (green). (E) Representative immunofluorescence images showing CD1c+ DCs, CD4+ T lymphocytes, CD8+ T lymphocytes, and CD20+ B lymphocytes expressing CCR7 in renal biopsies of CKD patients. (F) Interstitial inflammatory cells in LVs low group (n = 185) and LVshigh group (n = 93) CKD patient renal biopsy specimens. (G) Proteinuria, eGFR, intrarenal interstitial inflammatory cells, and fibrosis score in LVslow and LVshigh groups. Proteinuria grading: I, 0 to 1 g/24 hours; II, 1 to 2 g/24 hours; III, above 2 g/24 hours. eGFR grading: I, above 90 ml/min; II, 60 to 90 ml/min; III, below 60 ml/min. Inflammatory cells and interstitial fibrosis grading: I, mild; II, moderate; III, severe. Color-coded bars indicate different grades. (H) Representative images (40×) showing intrarenal fibrosis [Masson-trichrome staining (MTS) and fibronectin] of LVslow and LVshigh groups. Fifteen patients from each group are represented. Statistical analysis was performed using the Mann-Whitney U test. **P < 0.01, ***P < Values are mean ± SEM. Guangchang Pei et al. Sci Adv 2019;5:eaaw5075 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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